Publications

Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.

Meinke S, Goldammer G, Weber AI, Tarabykin V, Neumann A, Preussner M, Heyd F.

Elife. 2020 Apr 27;9. pii: e56075. doi: 10.7554/eLife.56075.

Amplitude effects allow short jet lags and large seasonal phase shifts in minimal clock models.

Ananthasubramaniam, B., Schmal, C., and Herzel, H (2020)

J. Mol. Biol. in press (Available at bioRxiv.org)

A conserved kinase-based body-temperature sensor globally controls alternative splicing and gene expression.

Haltenhof, T., Kotte, A., De Bortoli, F., Schiefer, S., Meinke, S., Emmerichs, A.K., Petermann, K.K., Timmermann, B., Imhof, P., Franz, A., Loll, B., Wahl, M.C., Preußner, M., and Heyd, F (2020)

Mol. Cell, in press (DOI: 10.1016/j.molcel.2020.01.028)

CDK1 couples proliferation with protein synthesis.

Haneke K, Schott J, Lindner D, Hollensen A, Damgaard C, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G (2020)

J Cell Biol, in press (doi.org/10-1083/jcb.201906147; Available at bioRxiv.org)

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring.

Kiral FR, Linneweber GA, Mathejczyk TF, Georgiev SV, Wernet MF, Hassan BA, von Kleist M, Hiesinger PR (2020)

Nat Commun, in press (Available at bioRxiv.org)

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogenous vesicle:Ca2+ channel distances.

Kobbersmed JRL, Grasskamp AT, Jusyte M, Böhme MA, Ditlevsen S, Sörensen JB, Walter AM (2020)

eLife, in press

Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis.

Kupke T, Klare JP, Brügger B (2020)

Commun Biol 14;3(1):73

The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells.

Legrand C, Saleppico R, Sticht J, Lolicato F, Müller HM, Wegehingel S, Dimou E, Steringer JP, Ewers H, Vattulainen I, Freund C, Nickel W (2020)

Commun Biol, in press (Available at bioRxiv.org)

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila.

Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, Beyersdörffer C, Frei J, Hess A, Kern K, Lange L, Langner N, Malamud R, Pavlovic B, Rädecke K, Schmitt L, Voos L, Valentini E, Boutros M (2020)

eLife, in press (Available at bioRxiv.org)

The inactive C-terminal cassette oft he dual-cassette RNA helicase BRR“ both stimulates and inhibits the activity oft he N-terminal helicase unit.

Vester K, Santos KF, Kuropka B, Weise C, Wahl MC (2020)

J Biol Chem 295:2097-2112

Molecular mechanism underlying inhibition of intrinsic ATPase activity in a Ski2-like RNA helicase.

Absmeier, E., Santos, K. F., Wahl, M. C. (2019).

Structure 28:236-243 https://www.biorxiv.org/content/10.1101/758169v1.

The ubiquitin-like modifier FAT10 interferes with SUMO activation.

Aichem, A., Sailer, C., Ryu, S., Catone, N., Stankovic-Valentin, N., Schmidtke, G., Melchior, F., Stengel, F. and Groettrup, M. (2019).

Nat Commun. 10, 4452.

A genome-edited Sept2-GFP cell line.

Banko, M., Mucha-Kruczynska, I., Weise, C., Heyd, F. and Ewers, H. (2019).

Cytoskeleton 76 (1), 73-82.

Onset of differentiation is posttranscriptionally controlled in adult neural stem cells.

Baser, A., Skabkin, M., Kleber, S., Dang, Y., Gülcüler Balta, G. S., Kalamakis, G., Göpferich, M., Carvajal Ibañez, D., Schefzik, R., Santos Lopez, A., Llorens Bobadilla, E., Schultz, C., Fischer, B., Martin-Villalba, A. (2019).

Nature 566:100-104.

Rapid active zone remodeling consolidates presynaptic potentiation.

Böhme, M. A., McCarthy, A. W., Grasskamp, A. T., Beuschel, C. B., Goel, P., Jusyte, M., Laber, D., Huang, S., Rey, U., Petzold, A., Lehmann, M., Göttfert, F., Haghighi, P., Hell, S. W., Owald, D., Dickman, D., Sigrist#, S. J., and Walter, A. M#. (2019).

Nat. Commun. 10, 1085; (#: correspondence).

Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology.

Börding, T., Abdo, A. N., Maier, B., Gabriel, C., Kramer, A. (2019).

Front Physiol. 10:577.

Differential interleukin-2 transcription kinetics render mouse but not human T cells vulnerable to splicing inhibition early after activation.

Bose, D., Neumann, A., Timmermann, B., Meinke, S., Heyd, F. (2019).

Mol Cell Biol 39:e00035-19.

The axonal membrane protein PRG2 inhibits PTEN and directs growth to branches.

Brosig, A.#, Fuchs, J.#, Ipek, F., Schrötter, S., Vadhvani, M., Szczepek, M., van Diepen, M., Holzhütter, T., Trimbuch, T., Gimber, N., Schmoranzer, J., Lieberam, I., Rosenmund, C., Spahn, C., Scheerer, P., Leondaritis, G. and Eickholt, B. (2019).

Cell Rep 29(7):2028-2040; (#: correspondence).

Hypoxia-induced changes in SUMO conjugation affect transcriptional regulation under low oxygen.

Chachami, G., Stankovic-Valentin, N., Karagiota, A., Basagianni, A., Plessmann, U., Urlaub, H., Melchior, F. and Simos, G. (2019).

Mol Cell Proteomics 18,1197-1209.

Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splic- ing factor PRPF39.

De Bortoli, F., Neumann, A., Kotte, A., Timmermann, B., Schuler, T., Wahl, M. C., Loll, B., Heyd, F. (2019).

Nucleic Acids Res 47:5867-5879.

Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness.

Wu, J., Ma, S., Sandhoff, R., Ming, Y., Hotz-Wagenblatt, A., Timmerman, V., Bonello-Palot, N., Schlotter-Weigel, B., Auer-Grumbach, M., Seeman, P., Löscher, W.N., Reindl, M., Weiss, F., Mah, E., Weisshaar, N., Madi, A., Mohr, K., Schlimbach, T., Velasco Cárdenas, R.M., Koeppel, J., Grünschläger, F., Müller, L., Baumeister, M., Brügger, B., Schmitt, M., Wabnitz, G., Samstag, Y., Cui, G. (2019).

Immunity S1074- 7613(19)30095-0.

Differential IL2 transcription kinetics render mouse but not human T cells vulnerable to splicing inhibition early after activation.

Bose, D., Neumann, A., Timmermann, B., Meinke, S., Heyd, F(2019).

Mol Cell Biol. 2019 Jun 3. pii: MCB.00035-19.

DOI: 10.1128/MCB.00035-19.

A Robust Model for Circadian Redox Oscillations.

del Olmo, M., Kramer, A., Herzel, H. (2019).

Int. J. Mol. Sci. 2019, 20(9), 2368.

DOI: 10.3390/ijms2009236.

Single event visualization of unconventional secretion of FGF2.

Dimou, E., Cosentino, K., Platonova, E., Ros, U., Sadeghi, M., Kashyap, P., Katsinelos, T., Wegehingel, S., Noé, F., García-Sáez ,A. J., Ewers, H., Nickel, W. (2018).

J Cell Biol. 2019 Feb 4;218(2):683-699. Epub 2018 Nov 23.

DOI: 10.1083/jcb.201802008.

An Inactivation Switch Enables Rhythms in a Neurospora Clock Model.

Upadhyay, A., Brunner, M., Herzel, H. (2019).

Int. J. Mol. Sci., 20(12), 2985.

DOI: 10.3390/ijms20122985.

A missing switch in peptide exchange for MHC class II molecules.

Freund, C. & Höfer, T. (2019).

Front. Immunol.

DOI: 10.3389/fimmu.2019.02513.

3D cellular architecture modulates tyrosine kinase activ- ity thereby switching CD95 mediated apoptosis to survival.

Gülcüler Balta, G. S., Monzel, C., Kleber, S., Beaudouin, J., Balta, E., Kaindl, T., Chen, S., Gao, L., Thiemann, M., Wirtz, C. R., Samstag, Y., Tanaka, M., Martin-Villalba, A. (2019).

Cell Reports (in press).

Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line.

Hauke, S., Dutta, A. K., Eisenbeis, V. B., Bezold, D., Bittner, T., Wittwer, C., Thakor, D., Pavlovic, I., Schultz, C., Jessen, H. J. (2019).

Chem. Sci. 10:2687-2692.

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress.

Höglinger, D., Burgoyne, T., Sanchez-Heras, E., Hartwig, P., Colaco, A., Newton, J., Futter, C., Spiegel, S., Platt, F., Eden, E. (2019).

Nat Commun, 10(1):4276-4289.

Bi- and Trifunctional Lipids for Visualization of Sphingolipid Dynamics within the Cell.

Höglinger, D. (2019).

Methods Mol Biol, 1949:95-103.

Illuminating G-Protein-Coupling Selectivity of GPCRs.

Inoue, A., Raimondi, F., Kadji, F. M. N., Singh, G., Kishi, T., Uwamizu, A., Ono, Y., Shinjo, Y., Ishida, S., Arang, N., Kawakami, K., Gutkind, J. S., Aoki, J., Russell, R. B. (2019).

Methods Mol Biol, 1949:95-103.

Onset of differentiation is posttranscriptionally controlled in adult neural stem cells.

Baser, A., Skabkin, M., Kleber, S., Dang, Y., Gülcüler Balta, G. S., Kalamakis, G., Göpferich, M., Ibañez, D. C., Schefzik, R., Lopez, A. S., Bobadilla, E. L., Schultz, C., Fischer, B., Martin-Villalba, A. (2019).

Nature 566:100-104.

Photo-release of 2-arachidonoylglycerol in live cells.

Laguerre, A., Hauke, S., Qiu, J., Kelly, M., Schultz, C. (2019).

J. Am. Chem. Soc. 141, 16544-16547.

Nanoscale coupling of endocytic pit growth and stability.

Lehmann, M., Lukonin, I., Noé, F., Schmoranzer, J., Clementi, C., Loerke, D., Haucke, V. (2019).

Sci Adv. 2019 Nov 27;5(11):eaax5775. eCollection 2019 Nov.

DOI: 10.1074/jbc.RA119.011774.

Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes.

Müksch, F., Cetir, M., Lüchtenborg, C., Glass, B., Traynor-Kaplan, A., Schultz, C., Brügger, B., Kräusslich, H. G. (2019).

Sci Reports, 9(1):17661.

DOI: 10.1038/s41598-019-53939-z.

Synthesis and cellular labeling of caged phosphatidylinositol derivatives.

Müller, R., Citir, M., Hauke, S., Schultz, C. (2019).

Chemistry.

DOI: 10.1002/chem.201903704.

Hypoxic environment promotes barrier formation in human intestinal epithelial cells through regulation of miRNA-320a expression.

Muenchau, S., Deutsch, R., de Castro, I. J., Hielscher, T., Heber, N., Niesler, B., Lusic, M., Stanifer, M. L., Boulant S. (2019).

Mol Cell Biol. 39(14). pii: e00553-18.

Dynamic graphical models of molecular kinetics.

Olsson, S., Noé F. (2019).

Proc. Natl. Acad. Sci. USA. 116(30): 15001-15006.

Serial synapse formation through filopodial competition for synaptic seeding factors.

Ozel, M. N., Kulkarni, A., Hasan, A., Brummer, J., Moldenhauer, M., Daumann, I. M., Wolfenberg, H., Dercksen, V. J., Kiral, F. R., Weiser, M., Prohaska, S., von Kleist, M., Hiesinger, P. R. (2019).

Dev Cell, 50(4):447-461.

Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis.

Poulsen, M. H., Poshtiban, A., Klippenstein, V., Ghisi. V, and Plested, A. J. R. (2019).

Proc Natl Acad Sci USA 116(27):13358-13367.

Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

Quade, B., Camacho, M., Zhao, X., Orlando, M., Trimbuch, T., Xu, J., Li, W., Nicastro, D., Rosenmund, C., and Rizo, J. (2019).

Elife 8, e42806

Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells.

Stanifer, M., Mukenhirn, M,. Muenchau, S., Pervolaraki, K., Kanaya, T., Albrecht, D., Haucke, V., Odendall, C., Ka- gan, J. C., Bartfeld, S., Ohno, H., and Boulant, S. (2019).

Nature Microbiology.

https://www.nature.com/articles/s41564-019-0594-3

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signaling via mTORC1.

Wallroth, A., Koch, P. A., Marat, A. L., Krause, E., Haucke, V. (2019).

Nat Cell Biol 21: 1093-1101.

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.

Wang, H., Loerke, D., Bruns, C., Müller, R., Koch, P. A., Puchkov, D., Schultz, C., Haucke, V. (2019).

J Biol Chem. 2019 Dec 12. pii: jbc.RA119.011774.

DOI: 10.1074/jbc.RA119.011774.

Mechanical signals regulate TORC2 activity.

Ebner, M., Haucke, V. (2018).

Nat. Cell Biol. 20: 994-995 (News and Views).

Quantitative analysis of circadian single cell oscillations in response to temperature

Abraham, U., Schlichting, J. K., Kramer, A., Herzel, H. (2018).

PLoS One. 2018 Jan 2;13(1):e0190004.

DOI: 10.1371/journal.pone.0190004

Ultradian Rhythms in the Transcriptome of Neurospora crassa.

Ananthasubramaniam, B., Diernfellner, A., Brunner, M., Herzel, H. (2018).

iScience. 2018 Nov 30;9:475-486. Epub 2018 Nov 10.

DOI: 10.1016/j.isci.2018.11.012

Regulation of synaptic release-site-Ca2+-channel coupling as a mechanism to control release probability and short-term plasticity

Bohme, M. A., Grasskamp, A. T., and Walter, A. M. (2018).

FEBS Lett. 2018 Nov;592(21):3516-3531. Epub 2018 Jul 31.

DOI: 10.1002/1873-3468.13188

Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment.

Chang, S., Trimbuch, T., Rosenmund, C(2018).

Nat Neurosci. 2018 Jan;21(1):33-40. Epub 2017 Dec 11.

DOI: 10.1038/s41593-017-0037-5

Unconventional mechanisms of eukaryotic protein secretion.

Dimou, E., Nickel, W. (2018).

Curr Biol. 2018 Apr 23;28(8):R406-R410. 

DOI: 10.1016/j.cub.2017.11.074

Open-source recombinant monoclonal secondary nanobodies.

Ewers, H. (2018).

J Cell Biol. 2018 Mar 5;217(3):809-811. Epub 2018 Feb 14.

DOI: 10.1083/jcb.201802025

Optical tools for understanding the complexity of beta cell signaling and insulin release.

Frank, J., Broichhagen, J., Yushchenko, D., Trauner, D., Schultz, C., Hodson, D. (2018).

Nat Rev Endocrinol. 2018 Dec;14(12):721-737.

DOI: 10.1038/s41574-018-0105-2

Surface Immobilization of Viruses and Nanoparticles Elucidates Early Events in Clathrin-mediated Endocytosis.

Fratini, M., Wiegand, T., Funaya, C., Spatz, J. P., Cavalcanti-Adam, E. A., Boulant, S. (2018).

ACS Infect Dis. 2018 Nov 9;4(11):1585-1600. Epub 2018 Sep 26.

DOI: 10.1021/acsinfecdis.8b00134

Expansion Stimulated Emission Depletion Microscopy (ExSTED).

Gao, M., Maraspini, R., Beutel, O., Zehtabian, A., Eickholt, B., Honigmann, A., Ewers, H. (2018).

ACS Nano. 2018 May 22;12(5):4178-4185. Epub 2018 Apr 19.

DOI: 10.1021/acsnano.8b00776

Endogenous Fatty Acids are Essential Autocrine Signaling Factors of Pancreatic β-Cells and Insulin Secretion.

Hauke, S., Keutler, K., Phapale, P., Yushchenko, D., Schultz, C. (2018).

Diabetes. 2018 Oct;67(10):1986-1998.

doi.org/10.2337/db17-1215

The Evolution of Variability and Robustness in Neural Development.

Hiesinger, P. R., Hassan, B. A. (2018).

Trends in Neuroscience 41(9):577-586.

DOI: 10.1016/j.tins.2018.05.007

The where, what, and when of membrane protein degradation in neurons.

Jin, E. J., Kiral, F. R., Hiesinger, P. R. (2018).

Dev Neurobiol. 2018 Mar;78(3):283-297. doi: 10.1002/dneu.22534. Epub 2017 Sep 19. Review.

Live observation of two parallel membrane degradation pathways at axon terminals.

Jin, E. J., Kiral, F. R., Özel, M. N., Burchardt, L. S., Osterland, M., Epstein, D., Wolfenberg, H., Prohaska, S., Hiesinger, P. R. (2018).

Curr. Biol., 28(7):1027-1038.e4.

DOI: 10.1016/j.cub.2018.02.032

PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.

Kath, C., Goni-Oliver, P., Müller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J. (2018).

PLoS One 13, e0193257. 

DOI: 10.1371/journal.pone.0193257

Unconventional secretion mediates the trans-cellular spreading of tau.

Katsilenos, T., Zeitler, M., Dimou, E., Karakatsani, A., Müller, H. M., Nachman, E., Steringer, J. P., Ruiz de Almodovar, C., Nickel, W., Jahn, T. R. (2018).

Cell Rep 23:2039-2055.

DOI: 10.1016/j.celrep.2018.04.056

Rab GTPases and Membrane Trafficking in Neurodegeneration.

Kiral, F. K., Kohrs, F., Jin, E. J. and Hiesinger, P. R. (2018).

Curr Biol. 2018 Apr 23;28(8):R471-R486. 

DOI: 10.1016/j.cub.2018.02.010

A potent and selective PARP11 inhibitor suggests coupling between cellular localization and catalytic activity.

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H., Cohen M. S. (2018).

Cell Chem Biol. 2018 Dec 20;25(12):1547-1553.e12. Epub 2018 Oct 18.

DOI: 10.1016/j.chembiol.2018.09.011

Novel lipid tools and probes for biological investigations.

Laguerre, A., Schultz, C. (2018).

Curr Opin Cell Biol. 2018 Aug;53:97-104. Epub 2018 Jul 14. Review.

DOI: 10.1016/j.ceb.2018.06.013

VAMPnets for deep learning of molecular kinetics.

Mardt, A, Pasquali, L., Wu, H., Noé, F. (2018).

Nature Communicationsvolume 9, Article number: 5 (https://www.nature.com/articles/s41467-017-02388-1)

DOI: 10.1038/s41467-017-02388-1

Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasomal inhibition.

Nowak, K., Taubert, R. M., Haberecht, S., Venz, S., Krüger, E. (2018).

Biosci Rep. 2018 Sep 3. pii: BSR20180393. [Epub ahead of print].

DOI: 10.1042/BSR20180393

Control of SUMO and Ubiquitin by ROS: Signaling and disease implications.

Stankovic-Valentin, N., Melchior, F. (2018).

Mol Aspects Med. 63, 3-17. (Review).

DOI: 10.1016/j.mam.2018.07.002

Autoregulation of class II alpha PI3K activity by its lipid binding PX-C2 domain module.

Wang, H., Lo, W. T., Vujičić Žagar, A., Gulluni, F., Scapozza, L., Haucke, V.*, Vadas, O.* (2018).

Mol. Cell, 71, 343-351(*co-corresponding authors).

DOI: 10.1016/j.molcel.2018.06.042

Phosphoinositide conversion in endocytosis and in the endolysosomal system.

Wallroth, A., Haucke, V. (2018).

J Biol Chem. 2018 Feb 2;293(5):1526-1535. Epub 2017 Dec 27.

DOI: 10.1074/jbc.R117.000629

Deep Generative Markov State Models.

Wu, H., Mardt, A., Pasquali, L., Noé, F., (2018).

32nd Conference on Neural Information Processing Systems (NeurIPS 2018), Montréal, Canada.

A click cage: Organelle-specific uncaging of lipid mes- sengers.

Wagner, N., Stephan, M., Höglinger, D., Nadler, A., (2018).

Angew Chem Int Ed Engl, 57:13339-13343.

Vesicle release site organization at synaptic active zones.

Walter, A. M.#, Bohme, M. A., and Sigrist, S. J.# (2018).

Neurosci Res 127, 3-13; (#:correspondence).

Co-existing feedback loops generate tissue- specific circadian rhythms.

Pett, J. P., Kondoff, M., Bordyugov, G., Kramer, A., Herzel, H. (2018).

Life Sci Alliance 1:e201800078.

Heterozygous truncating variants in POMP escape nonsense-mediated decay and cause a unique immune dysregulatory syndrome.

Poli, M. C., Ebstein, F., Nicholas, S. K., de Guzman, M. M., Forbes, L. R., Chinn, I. K., Mace, E. M., Vogel, T. P., Carisey, A. F., Benavides, F., Coban-Akdemir, Z. H., Gibbs, R. A., Jhangiani, S. N., Muzny, D. M., Carvalho, C. M. B., Schady, D. A., Jain, M., Rosenfeld, J. A., Emrick, L., Lewis, R. A., Lee, B., Undiagnosed Diseases Network members, Zieba, B. A., Küry, S., Krüger, E., Lupski, J. R., Bostwick, B. L., Orange, J. S. (2018).

Am. J. Hum. Genet. 102(6):1126-1142.

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1beta.

Brough, D., Pellegrin, P., and Nickel, W. (2017).

J Cell Sci 130:3197-3202.

DOI: 10.1242/jcs.204206

The coding and noncoding transcriptome of Neurospora crassa.

Cemel, I. A., Ha, N., Schermann, G., Yonekawa, S., Brunner, M. (2017).

BMC Genomics, 18(1), 978.

DOI: 10.1186/s12864-017-4360-8

Optical control of GPR40 signalling in pancreatic ß-cells.

Frank, J. A., Yushchenko, D. A., Fine, N. H. F., Duca, M., Citir, M., Broichhagen, J., Hodson, D. J., Schultz, C., Trauner, D. (2017).

Chem. Sci. 8, 7604-7610.

DOI: 10.1039/c7sc01475a

Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.

Höglinger, D., Nadler, A., Haberkant, P., Kirkpatrick, J., Schifferer, M., Stein, F., Hauke, S., Porter, F. D., Schultz, C. (2017).

Proc. Natl. Acad. Sci. USA 114, 1566-1571.

DOI: 10.1073/pnas.1611096114

Reciprocal regulation of carbon monoxide metabolism and the circadian clock.

Klemz, R., Reischl, S., Wallach, T., Witte, N., Jürchott, K., Klemz, S., Lang, V., Lorenzen, S., Knauer, M., Heidenreich, S., Xu, M., Ripperger, J. A., Schupp, M., Stanewsky, R., Kramer, A. (2017).

Nat Struct Mol Biol. 2017 Jan;24(1):15-22.

DOI: 10.1073/pnas.1611096114

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.

Lauinger, L., Li, J., Shostak, A., Cemel, I. A., Ha, N., Zhang, Y., Merkl, P. E., Obermeyer, S., Stankovic-Valentin, N., Schafmeier, T., Wever, W. J., Bowers, A. A., Carter, K. P., Palmer, A. E., Tschochner, H., Melchior, F., Deshaies, R. J., Brunner, M., Diernfellner, A. (2017).

Nat Chem Biol. 2017 Jul;13(7):709-714.

DOI: 10.1038/nchembio.2370

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.

Marat, A. L., Wallroth, A., Lo, W. T., Müller, R., Norata, G. D., Falasca, M., Schultz, C., Haucke, V. (2017).

Science. 2017 Jun 2;356(6341):968-972

DOI: 10.1126/science.aaf8310

 

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.

Piwecka, M., Glažar, P., Hernandez-Miranda, L. R., Memczak, S., Wolf, S. A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C. A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C., Rajewsky, N. (2017).

Science. 2017 Sep 22;357(6357). pii: eaam8526

DOI: 10.1126/science.aam8526

Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Reddy-Alla, S., Böhme, M. A., Reynolds, E., Beis, C., Grasskamp, A. T., Mampell, M. M., Maglione, M., Jusyte, M., Rey, U., Babikir, H., McCarthy, A. W., Quentin, C., Matkovic, T., Bergeron, D .D., Mushtaq, Z., Göttfert, F., Owald, D., Mielke, T., Hell, S. W., Sigrist, S. J.Walter, A. M(2017).

Neuron. 2017 Sep 13;95(6):1350-1364.e12.

DOI: 10.1016/j.neuron.2017.08.016

Flavivirus infection uncouples translation suppression from cellular stress responses.

Roth, H., Magg, V., Uch, F., Mutz, P., Klein, P., Haneke, K., Lohmann, V., Bartenschlager, R., Fackler, O.T., Locker, N., Stoecklin, G., Ruggieri, A. (2017)

MBio. 2017 Jan 10;8(1). pii: e02150-16.

DOI: 10.1128/mBio.02150-16

A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells.

Schifferer, M., Yushchenko, D. A., Hodson, D. J., Bolbat, A., Stein, F., Schultz, C. (2017).

Cell Chem Biol. 2017 Apr 20;24(4):525-531.e4.

DOI: 10.1016/j.chembiol.2017.03.001

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components.

Steringer, J. P., Lange, S., Čujová, S., Šachl, R., Poojari, C., Lolicato, F., Beutel, O., Müller, H.M., Unger, S., Coskun, Ü., Honigmann, A., Vattulainen I, Hof, M., Freund, C., Nickel, W. (2017).

Elife. 2017 Jul 19;6. pii: e28985.

DOI: 10.7554/eLife.28985

Principles for circadian orchestration of metabolic pathways.

Thurley, K., Herbst, C., Wesener, F., Koller, B., Wallach, T., Maier B, Kramer, A., Westermark, P. O. (2017).

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1572-1577.

DOI: 10.1073/pnas.1613103114

A lipid off-switch for mTORC1.

Wallroth, A., Haucke, V(2017).

Mol. Cell. Oncol. 4:e1356899.

DOI: 10.1080/23723556.2017.1356899

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

Walter, A. M., Müller, R., Tawfik, B., Wierda, K. D., Pinheiro, P. S., Nadler, A., McCarthy, A. W., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Lehmann, M., Haucke, V., Hille, B., Schultz, C., Sorensen, J. B. (2017).

Elife. 2017 Oct 25;6. pii: e30203.

DOI: 10.7554/eLife.30203

Wiring visual systems: common and divergent mechanisms and principles.

Kolodkin, A. L. and Hiesinger, P. R. (2017).

Curr. Opin. Neurobiol. 42:128-135.

The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles.

Trautz B., Wiedemann, H., Lüchtenborg, C., Pierini, V., Kranich, J., Glass, B., Kräusslich, H. G., Brocker, T., Pizzato, M., Ruggieri, A., Brügger, B., Fackler, O. T. (2017).

J Biol Chem. 292(33):13702-13713.

Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

Paul, F., Wehmeyer, C., Abualrous, E. T., Wu, H., Crabtree. M. D., Schöneberg, J., Clarke, J., Freund, C., Weikl, T. R., Noé, F. (2017).

Nat. Commun. 8, 1095.

MHC class II complexes sample intermediate states along the peptide exchange pathway

Wieczorek, M., Sticht, J., Stolzenberg, S., Günther, S., Wehmeyer, C,. El Habre, Z., Alvaro-Benito, M., Noé, F.*, Freund, C*. (2017).

Nature Communications 7, 13224 (2017)

DOI: 10.1038/ncomms13224

Photoswitchable diacylglycerols enable optical control of protein kinase C.

Frank, J. A., Yushchenko, D. A., Hodson, D. J., Lipstein, N., Nagpal, J., Rutter, G. A., Rhee, J.-S., Gottschalk, A., Brose, N., Schultz*, C., Trauner*, D. (2016).

Nat. Chem. Biol. 12, 755-762 (2016).

DOI: 10.1038/nchembio.2141

Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2.

La Venuta, G., Wegehingel, S., Sehr, P., Müller, H. M., Dimou, E., Steringer, J. P., Grotwinkel, M., Hentze, N., Mayer, M. P., Will, D. W., Uhrig, U., Lewis, J. D., Nickel, W. (2016).

J Biol Chem. 2016 Aug 19;291(34):17787-803.

DOI: 10.1074/jbc.M116.729384

Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator.

Pett, J. P., Korenčič, A., Wesener, F., Kramer, A., Herzel, H. (2016).

PLoS Comput Biol. 2016 Dec 12;12(12):e1005266.

DOI: 10.1371/journal.pcbi.1005266

Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission.

Schupp, M., Malsam, J., Ruiter, M., Scheutzow, A., Wierda, K. D., Söllner, T. H. and Sørensen, J. B. (2016).

J Neurosci 36, 11865-11880.

TCF11/Nrf1-mediated induction of proteasome expression prevents cytotoxicity by rotenone.

Sotzny ,F., Schormann, E., Kühlewindt, I., Koch, A., Brehm, A., Goldbach-Mansky, R., Gilling, K. E., Krüger, E. (2016).

Antioxid. Redox. Signal 25:870-885.

Amplitude effects allow short jetlags and large sea- sonal phase shifts in minimal clock models.

Ananthasubramaniam, B., Schmal, C., Herzel, H. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/825331v2

Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling.

Barysch, S. V., Stankovic-Valentin, N., Karaca, S., Doppel, J., Achour, T. N., Sticht, C., Urlaub, H. and Melchior, F. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/819730v1

CDK1 couples proliferation with protein synthesis.

Haneke, K., Schott, H., Lindner, D., Hollensen, A. K., Daamgard, C. K., Mongis, C., Knop, M., Palm, W., Ruggieri, A., Stoecklin, G. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/816850v1

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring.

Kiral, F. R., Linneweber, G. A., Georgiev, S. V., Hassan, B. A., von Kleist, M., Hiesinger, P. R. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/762179v1

Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness in Drosophila.

Kohrs FE, Daumann IM, Pavlovic B, Jin EJ, Lin SC, Port F, Kiral FR, Wolfenberg H, Chan CC, Boutros M, Hiesinger PR (2020)

bioRxiv.org

The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells.

Legrand, C., Saleppico, R., Sticht, J., Lolicato, F., Müller, H. M., Wegehingel, S., Dimou, E., Steringer, J. P., Ewers, H., Vattulainen, I., Freund, C., Nickel, W. (2019).

bioRxivhttp://biorxiv.org/cgi/content/short/827691v1

Complexin suppresses spontaneous exocytosis by capturing the membrane-proximal regions of VAMP2 and SNAP25.

Malsam, J., Bärfuss, S., Trimbuch, T., Zarebidaki, F., Sonnen, A. F.-P., Wild, K., Scheutzow A., Sinning, I., Briggs, J. A. G., Rosenmund, C., Söllner, T. H. (2019).

bioRxivhttps://biorxiv.org/cgi/content/short/849885v1

Dynamic Palmitoylation Events Following T-Cell Receptor Signaling.

Morrison, E., Wegner, T., Zucchetti, A. E., Álvaro-Benito, M., Zheng, A., Kliche, S., Krause, E., Brügger, B., Hivroz, C. & Freund, C. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/831388v1

Heritable gene expression variability governs clonal heterogeneity in circadian period.

Nikhil, K. L., Korge, S., Kramer, A. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/731075v2

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila.

Port, F., Strein, C., Stricker, M., Rauscher, B., Heigwer, F., Zhou, J., Beyersdörffer, C., Frei, J., Hess, A., Kern, K., Malamud, R., Pavlovic, B., Rädecke, K., Schmitt, L., Voos, L., Valentini, E., Boutros, M. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/636076v1

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila.

Shostak, A., Schermann, G., Diernfellner, A., Brunner, M. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/842799v1

Global Transcriptome Char- acterization and Assembly of Thermophilic Ascomycete Chaetomium thermophilum.

Singh, A., Schermann, G., Reisloehner, S., Kellner, N., Hurt, E., Brunner, M. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/826354v1

Positive and negative intra-molecular modulation in a dual-cassette RNA helicase.

Vester, K., Santos, K. F., Kuropka, B., Weise, C., Wahl, M. C. (2019).

bioRxivhttps://www.biorxiv.org/content/10.1101/758698v1