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A Robust Model for Circadian Redox Oscillations

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Int. J. Mol. Sci. 2019, 20(9), 2368.

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Single event visualization of unconventional secretion of FGF2

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J Cell Biol. 2019 Feb 4;218(2):683-699. Epub 2018 Nov 23.

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An Inactivation Switch Enables Rhythms in a Neurospora Clock Model

Upadhyay, A., Brunner, M., Herzel, H. (2019)

Int. J. Mol. Sci., 20(12), 2985.

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Quantitative analysis of circadian single cell oscillations in response to temperature

Abraham, U., Schlichting, J. K., Kramer, A., Herzel, H.

PLoS One. 2018 Jan 2;13(1):e0190004.

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Ultradian Rhythms in the Transcriptome of Neurospora crassa

Ananthasubramaniam, B., Diernfellner, A., Brunner, M., Herzel, H.

iScience. 2018 Nov 30;9:475-486. Epub 2018 Nov 10.

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Nat Neurosci. 2018 Jan;21(1):33-40. Epub 2017 Dec 11.

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Optical tools for understanding the complexity of beta cell signaling and insulin release

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Nat Rev Endocrinol. 2018 Dec;14(12):721-737.

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Surface Immobilization of Viruses and Nanoparticles Elucidates Early Events in Clathrin-mediated Endocytosis

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ACS Infect Dis. 2018 Nov 9;4(11):1585-1600. Epub 2018 Sep 26.

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Endogenous Fatty Acids are Essential Autocrine Signaling Factors of Pancreatic β-Cells and Insulin Secretion

Hauke, S., Keutler, K., Phapale, P., Yushchenko, D., Schultz, C.

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The Evolution of Variability and Robustness in Neural Development

Hiesinger, P. R., Hassan, B. A.

Trends in Neuroscience 41(9):577-586

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The where, what, and when of membrane protein degradation in neurons

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Dev Neurobiol. 2018 Mar;78(3):283-297. doi: 10.1002/dneu.22534. Epub 2017 Sep 19. Review.

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PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules

Kath, C., Goni-Oliver, P., Müller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J.

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Unconventional secretion mediates the trans-cellular spreading of tau

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Cell Rep 23:2039-2055.

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Rab GTPases and Membrane Trafficking in Neurodegeneration

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Curr Biol. 2018 Apr 23;28(8):R471-R486. 

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A potent and selective PARP11 inhibitor suggests coupling between cellular localization and catalytic activity

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H., Cohen M. S.

Cell Chem Biol. 2018 Dec 20;25(12):1547-1553.e12. Epub 2018 Oct 18.

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Novel lipid tools and probes for biological investigations

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Curr Opin Cell Biol. 2018 Aug;53:97-104. Epub 2018 Jul 14. Review.

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VAMPnets for deep learning of molecular kinetics

Mardt, A, Pasquali, L., Wu, H., Noé, F.

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Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasomal inhibition

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Control of SUMO and Ubiquitin by ROS: Signaling and disease implications.

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Autoregulation of class II alpha PI3K activity by its lipid binding PX-C2 domain module

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Phosphoinositide conversion in endocytosis and in the endolysosomal system

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J Biol Chem. 2018 Feb 2;293(5):1526-1535. Epub 2017 Dec 27.

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Deep Generative Markov State Models

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An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1beta

Brough, D., Pellegrin, P., and Nickel, W.

J Cell Sci 130:3197-3202

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The coding and noncoding transcriptome of Neurospora crassa

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Optical control of GPR40 signalling in pancreatic ß-cells

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Chem. Sci. 8, 7604-7610 (2017)

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Trifunctional lipid probes for comprehensive studies of single lipid species in living cells

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Reciprocal regulation of carbon monoxide metabolism and the circadian clock.

Klemz, R., Reischl, S., Wallach, T., Witte, N., Jürchott, K., Klemz, S., Lang, V., Lorenzen, S., Knauer, M., Heidenreich, S., Xu, M., Ripperger, J. A., Schupp, M., Stanewsky, R., Kramer, A.

Nat Struct Mol Biol. 2017 Jan;24(1):15-22

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Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.

Lauinger, L., Li, J., Shostak, A., Cemel, I. A., Ha, N., Zhang, Y., Merkl, P. E., Obermeyer, S., Stankovic-Valentin, N., Schafmeier, T., Wever, W. J., Bowers, A. A., Carter, K. P., Palmer, A. E., Tschochner, H., Melchior, F., Deshaies, R. J., Brunner, M., Diernfellner, A.

Nat Chem Biol. 2017 Jul;13(7):709-714

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mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.

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Science. 2017 Jun 2;356(6341):968-972

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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.

Piwecka, M., Glažar, P., Hernandez-Miranda, L. R., Memczak, S., Wolf, S. A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C. A., Fenske, P., Trimbuch, T., Zywitza, V., Plass, M., Schreyer, L., Ayoub, S., Kocks, C., Kühn, R., Rosenmund, C., Birchmeier, C., Rajewsky, N.

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Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Reddy-Alla, S., Böhme, M. A., Reynolds, E., Beis, C., Grasskamp, A. T., Mampell, M. M., Maglione, M., Jusyte, M., Rey, U., Babikir, H., McCarthy, A. W., Quentin, C., Matkovic, T., Bergeron, D .D., Mushtaq, Z., Göttfert, F., Owald, D., Mielke, T., Hell, S. W., Sigrist, S. J.Walter, A. M.

Neuron. 2017 Sep 13;95(6):1350-1364.e12

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Flavivirus infection uncouples translation suppression from cellular stress responses

Roth, H., Magg, V., Uch, F., Mutz, P., Klein, P., Haneke, K., Lohmann, V., Bartenschlager, R., Fackler, O.T., Locker, N., Stoecklin, G., Ruggieri, A.

MBio. 2017 Jan 10;8(1). pii: e02150-16

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A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells

Schifferer, M., Yushchenko, D. A., Hodson, D. J., Bolbat, A., Stein, F., Schultz, C.

Cell Chem Biol. 2017 Apr 20;24(4):525-531.e4

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Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components.

Steringer, J. P., Lange, S., Čujová, S., Šachl, R., Poojari, C., Lolicato, F., Beutel, O., Müller, H.M., Unger, S., Coskun, Ü., Honigmann, A., Vattulainen I, Hof, M., Freund, C., Nickel, W.

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Principles for circadian orchestration of metabolic pathways.

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Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1572-1577

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A lipid off-switch for mTORC1

Wallroth, A., Haucke, V.

Mol. Cell. Oncol. 4:e1356899

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Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

Walter, A. M., Müller, R., Tawfik, B., Wierda, K. D., Pinheiro, P. S., Nadler, A., McCarthy, A. W., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Lehmann, M., Haucke, V., Hille, B., Schultz, C., Sorensen, J. B.

Elife. 2017 Oct 25;6. pii: e30203

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Photoswitchable diacylglycerols enable optical control of protein kinase C.

Frank, J. A., Yushchenko, D. A., Hodson, D. J., Lipstein, N., Nagpal, J., Rutter, G. A., Rhee, J.-S., Gottschalk, A., Brose, N., Schultz*, C., Trauner*, D.

Nat. Chem. Biol. 12, 755-762 (2016)

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Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2.

La Venuta, G., Wegehingel, S., Sehr, P., Müller, H. M., Dimou, E., Steringer, J. P., Grotwinkel, M., Hentze, N., Mayer, M. P., Will, D. W., Uhrig, U., Lewis, J. D., Nickel, W.

J Biol Chem. 2016 Aug 19;291(34):17787-803

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Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator.

Pett, J. P., Korenčič, A., Wesener, F., Kramer, A., Herzel, H.

PLoS Comput Biol. 2016 Dec 12;12(12):e1005266

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MHC class II complexes sample intermediate states along the peptide exchange pathway

Wieczorek, M., Sticht, J., Stolzenberg, S., Günther, S., Wehmeyer, C,. El Habre, Z., Alvaro-Benito, M., Noé, F.*, Freund, C*.

Nature Communications 7, 13224 (2016)

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