Publications

Synthesis and cellular labeling of multifunctional phosphatidylinositol bis- and trisphosphate derivatives

Mueller, R., Kojic, A., Citir, M., Schultz, C. (2021).

Angew. Chem. Int. Engl. (2021), accepted.

Caged lipids for subcellular manipulation

Farley, S., Laguerre, A., Schultz, C. (2021).

Curr. Op. Chem. Biol. (2021), accepted.

Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling

Sina V Barysch,†, Nicolas Stankovic-Valentin,†, Tim Miedema, Samir Karaca, Judith Doppel, Thiziri Nait Achour, Aarushi Vasudeva, Lucie Wolf, Carsten Sticht, Henning Urlaub & Frauke Melchior* (2021).

EMBO Rep (2021)e49651.

DOI: 10.15252/embr.201949651.

*Corresponding author. † These authors contributed equally to this work

Role of Clathrin Light Chains in Regulating Invadopodia Formation

Mukenhirn, M., Muraca, F., Bucher, D., Asberger, E., Cappio Barazzone, E., Cavalcanti-Adam, E.A., Boulant, S. (2021).

Cells. 2021; 10(2):451.

DOI: https://doi.org/10.3390/cells10020451.

Independent Markov Decomposition: Towards modeling kinetics of biomolecular complexes

Hempel, T., del Razo, M. J., Lee, C. T., Taylor, B. C., Amaro, R. E., Noé, F. (2021).

https://www.biorxiv.org/content/10.1101/2021.03.24.436806v1.

DOI: https://doi.org/10.1101/2021.03.24.436806.

Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat

Hempel, T., Raich, L., Olsson, S., Azouz, N.P., Klingler, A.M., Hoffmann, M., Pöhlmann, S., Rothenberg, M. E., Noé, F. (2021).

Chemical Science 12 (3), 983-992    6    2021.

DOI: https://doi.org/10.1039/D0SC05064D.

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

Hoffmann, M., Hofmann-Winkler, H., Smith, J.C., Krüger, N., Arora, P., Sørensen, L.K., Søgaard, O.S., Hasselstrøm, J.B., Winkler, M., Hempel, T., Raich, L., Olsson. S., Danov, O., Jonigk, D., Yamazoe, T., Yamatsuta, K., Mizuno, H., Ludwig, S., Noé, F., Kjolby, M., Braun, A., Sheltzer, J.M., Pöhlmann, S. (2021).

EBioMedicine, 103255    15    2021.

DOI: 10.1016/j.ebiom.2021.103255.

The molecular mechanisms mediating class II PI 3-kinase function in cell physiology

Koch, P.A., Dornan, G.L., Hessenberger, M., Haucke, V. (2021).

FEBS J.Online ahead of print.

DOI: 10.1111/febs.15692.

Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus

Geertsema, H. J., Aimola, G., Fabricius, V., Fuerste, J.P., Kaufer, B.B., Ewers, H. (2021).

Nature Biotechnology 39 (5), 551-554.

Directed manipulation of membrane proteins by fluorescent magnetic nanoparticles

Li, J.H., Santos-Otte, P., Au, B., Rentsch, J., Block, S., Ewers, H. (2021).

Nature communications 11 (1), 1-7.

Unblending of transcriptional condensates in human repeat expansion disease

Basu, S. , Mackowiak, S. D., Niskanen, H., Knezevic, D., Asimi, V., Grosswendt, S., Geertsema, H., Ali, S., Jerković, I., Ewers, H., Mundlos, S., Meissner, A, Ibrahim, D.M., Hnisz, D. (2021).

Cell 181 (5), 1062-1079. e30.

The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis

Correa-Vázquez, J.F., Juárez-Vicente, F., García-Gutiérrez, P., Barysch, S.V., Melchior, F., García-Domínguez, M. (2021).

Cell Death Dis. 2021 Mar 22;12(4):305. PMID: 33753728; PMCID: PMC7985304.

DOI: 10.1038/s41419-021-03590-2.

Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity

Klemz, S., Wallach, T., Korge, S., Rosing, M., Klemz, R., Maier, B., C. Fiorenza, N. C., Kaymak, I., Fritzsche, A. K., Herzog, E. D., Stanewsky, R., Kramer, A.

Genes & Development, in press.

Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

Gabriel, C. H., del Olmo, M., Zehtabian, A., Jäger, M., Reischl, S., van Dijk, H., Ulbricht, C., Rakhymzhan, A., Korte, T., Koller, B., Grudziecki, A., Maier, B., Herrmann, A., Niesner, R., Zemojtel, T., Ewers, H.,, Granada, A. E., Herzel, H.-P., Krame, A. (2021).

Nature Communications, in press.

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

Finger, A.-M., Jäschke, S., del Olmo, M., Hurwitz, R., Granada, A. E., Herzel, H.-P., Kramer, A. (2021).

Science Advances, in press.

Peripheral clocks tick independently of their master

Anna-Marie Finger and Achim Kramer (2021).

Genes & Development 35, 304-306.

DOI: https://doi.org/10.1101/gad.348305.121.

Mammalian circadian systems: Organization and modern life challenges

Anna-Marie Finger and Achim Kramer (2021).

Acta Physiol (Oxf) 231(3):e13548.

DOI: https://doi.org/10.1111/apha.13548.

Mechanisms underlying the complex dynamics of temperature entrainment by a circadian clock.

Burt, P., Grabe, S., Madeti, C., Upadhyay, A., Merrow, M., Roenneberg, T., Herzel, H., Schmal, C. (2021).

bioRxiv, 2021.

DOI: https://doi.org/10.1101/2021.04.28.441752.

Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.

Meinke, S., Goldammer, G., Weber, A.I., Tarabykin, V., Neumann, A., Preussner, M., Heyd, F. (2020).

Elife. 2020 Apr 27;9. pii: e56075.

DOI: 10.7554/eLife.56075.

Amplitude effects allow short jet lags and large seasonal phase shifts in minimal clock models.

Ananthasubramaniam, B., Schmal, C., and Herzel, H. (2020).

J. Mol. Biol. in press (Available at bioRxiv.org).

A conserved kinase-based body-temperature sensor globally controls alternative splicing and gene expression.

Haltenhof, T., Kotte, A., De Bortoli, F., Schiefer, S., Meinke, S., Emmerichs, A.K., Petermann, K.K., Timmermann, B., Imhof, P., Franz, A., Loll, B., Wahl, M.C., Preußner, M., and Heyd, F. (2020).

Mol. Cell, in press.

DOI: 10.1016/j.molcel.2020.01.028.

CDK1 couples proliferation with protein synthesis.

Haneke, K., Schott, J., Lindner, D., Hollensen, A., Damgaard, C., Mongis, C., Knop, M., Palm, W., Ruggieri, A., Stoecklin, G. (2020).

J Cell Biol, in press.

DOI: doi.org/10-1083/jcb.201906147 (Available at bioRxiv.org).

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring.

Kiral, F.R., Linneweber, G.A., Mathejczyk, T.F., Georgiev, S.V., Wernet, M.F., Hassan, B.A., von Kleist, M., Hiesinger, P.R. (2020).

Nat Commun, in press (Available at bioRxiv.org).

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogenous vesicle:Ca2+ channel distances.

Kobbersmed, J.R.L., Grasskamp, A.T., Jusyte, M., Böhme, M.A., Ditlevsen, S., Sörensen, J.B., Walter, A.M. (2020).

eLife, in press.

Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis.

Kupke, T., Klare, J.P., Brügger, B. (2020).

Commun Biol 14;3(1):73.

The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells.

Legrand, C., Saleppico, R., Sticht, J., Lolicato, F., Müller, H.M., Wegehingel, S., Dimou, E., Steringer, J.P., Ewers, H., Vattulainen, I., Freund, C., Nickel, W.  (2020).

Commun Biol, in press (Available at bioRxiv.org).

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila.

Port, F., Strein, C., Stricker, M., Rauscher, B., Heigwer, F., Zhou, J., Beyersdörffer, C., Frei, J., Hess, A., Kern, K., Lange, L., Langner, N., Malamud, R., Pavlovic, B., Rädecke, K., Schmitt, L., Voos, L., Valentini, E., Boutros, M. (2020).

eLife, in press (Available at bioRxiv.org).

The inactive C-terminal cassette oft he dual-cassette RNA helicase BRR“ both stimulates and inhibits the activity oft he N-terminal helicase unit.

Vester, K., Santos, K.F., Kuropka, B., Weise, C., Wahl, M.C. (2020).

J Biol Chem 295:2097-2112.

Deep learning Markov and Koopman models with physical constraints

Mardt, A., Pasquali, L., Noé, F., & Wu, H. (2020, August).

In Mathematical and Scientific Machine Learning (pp. 451-475). PMLR. arXiv:1912.07392 [physics.comp-ph].

Coupling of conformational switches in calcium sensor unraveled with local Markov models and transfer entropy

Hempel, T., Plattner, N., Noé, F. (2020).

Journal of Chemical Theory and Computation 16 (4), 2584-2593.

DOI: 10.1021/acs.jctc.0c00043.

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer

Liu, H., Paddock, M.N. Wang, H., Murphy, C.J., Geck, R.C., Navarro, A.J., Wulf, G.M., Elemento, O., Haucke, V., Cantley, L.C., Toker, A. (2020).

Cancer Discov. 10, 1226-1239.

DOI: 10.1158/2159-8290.

Heritable gene expression variability and stochasticity govern clonal heterogeneity in circadian period

Nikhil, K. L., Sandra Korge. S., Kramer, A. (2020).

PLoS Biol. 18:e3000792.

DOI: https://doi.org/10.1371/journal.pbio.3000792.

Coupled network of the circadian clocks: a driving force of rhythmic physiology

Finger, A.-M., Dibner, C., Kramer, A. (2020).

FEBS Lett. 594, 2734-2769.

DOI: https://doi.org/10.1002/1873-3468.13898.

Multiple random phosphorylations in clock proteins provide long delays and switches.

Upadhyay, A., Marzoll, D., Diernfellner, A., Brunner, M., Herzel, H. (2020). 

Sci. Rep. 10(1), 1-13, 2020; https://www.nature.com/articles/s41598-020-79277-z.

DOI: https://doi.org/10.1038/s41598-020-79277-z.

Molecular mechanism underlying inhibition of intrinsic ATPase activity in a Ski2-like RNA helicase.

Absmeier, E., Santos, K. F., Wahl, M. C. (2019).

Structure 28:236-243 https://www.biorxiv.org/content/10.1101/758169v1.

The ubiquitin-like modifier FAT10 interferes with SUMO activation.

Aichem, A., Sailer, C., Ryu, S., Catone, N., Stankovic-Valentin, N., Schmidtke, G., Melchior, F., Stengel, F. and Groettrup, M. (2019).

Nat Commun. 10, 4452.

A genome-edited Sept2-GFP cell line.

Banko, M., Mucha-Kruczynska, I., Weise, C., Heyd, F. and Ewers, H. (2019).

Cytoskeleton 76 (1), 73-82.

Onset of differentiation is posttranscriptionally controlled in adult neural stem cells.

Baser, A., Skabkin, M., Kleber, S., Dang, Y., Gülcüler Balta, G. S., Kalamakis, G., Göpferich, M., Carvajal Ibañez, D., Schefzik, R., Santos Lopez, A., Llorens Bobadilla, E., Schultz, C., Fischer, B., Martin-Villalba, A. (2019).

Nature 566:100-104.

Rapid active zone remodeling consolidates presynaptic potentiation.

Böhme, M. A., McCarthy, A. W., Grasskamp, A. T., Beuschel, C. B., Goel, P., Jusyte, M., Laber, D., Huang, S., Rey, U., Petzold, A., Lehmann, M., Göttfert, F., Haghighi, P., Hell, S. W., Owald, D., Dickman, D., Sigrist#, S. J., and Walter, A. M#. (2019).

Nat. Commun. 10, 1085; (#: correspondence).

Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology.

Börding, T., Abdo, A. N., Maier, B., Gabriel, C., Kramer, A. (2019).

Front Physiol. 10:577.

Differential interleukin-2 transcription kinetics render mouse but not human T cells vulnerable to splicing inhibition early after activation.

Bose, D., Neumann, A., Timmermann, B., Meinke, S., Heyd, F. (2019).

Mol Cell Biol 39:e00035-19.

The axonal membrane protein PRG2 inhibits PTEN and directs growth to branches.

Brosig, A.#, Fuchs, J.#, Ipek, F., Schrötter, S., Vadhvani, M., Szczepek, M., van Diepen, M., Holzhütter, T., Trimbuch, T., Gimber, N., Schmoranzer, J., Lieberam, I., Rosenmund, C., Spahn, C., Scheerer, P., Leondaritis, G. and Eickholt, B. (2019).

Cell Rep 29(7):2028-2040; (#: correspondence).

Hypoxia-induced changes in SUMO conjugation affect transcriptional regulation under low oxygen.

Chachami, G., Stankovic-Valentin, N., Karagiota, A., Basagianni, A., Plessmann, U., Urlaub, H., Melchior, F. and Simos, G. (2019).

Mol Cell Proteomics 18,1197-1209.

Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splic- ing factor PRPF39.

De Bortoli, F., Neumann, A., Kotte, A., Timmermann, B., Schuler, T., Wahl, M. C., Loll, B., Heyd, F. (2019).

Nucleic Acids Res 47:5867-5879.

Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness.

Wu, J., Ma, S., Sandhoff, R., Ming, Y., Hotz-Wagenblatt, A., Timmerman, V., Bonello-Palot, N., Schlotter-Weigel, B., Auer-Grumbach, M., Seeman, P., Löscher, W.N., Reindl, M., Weiss, F., Mah, E., Weisshaar, N., Madi, A., Mohr, K., Schlimbach, T., Velasco Cárdenas, R.M., Koeppel, J., Grünschläger, F., Müller, L., Baumeister, M., Brügger, B., Schmitt, M., Wabnitz, G., Samstag, Y., Cui, G. (2019).

Immunity S1074- 7613(19)30095-0.

Differential IL2 transcription kinetics render mouse but not human T cells vulnerable to splicing inhibition early after activation.

Bose, D., Neumann, A., Timmermann, B., Meinke, S., Heyd, F(2019).

Mol Cell Biol. 2019 Jun 3. pii: MCB.00035-19.

DOI: 10.1128/MCB.00035-19.

A Robust Model for Circadian Redox Oscillations.

del Olmo, M., Kramer, A., Herzel, H. (2019).

Int. J. Mol. Sci. 2019, 20(9), 2368.

DOI: 10.3390/ijms2009236.

Single event visualization of unconventional secretion of FGF2.

Dimou, E., Cosentino, K., Platonova, E., Ros, U., Sadeghi, M., Kashyap, P., Katsinelos, T., Wegehingel, S., Noé, F., García-Sáez ,A. J., Ewers, H., Nickel, W. (2018).

J Cell Biol. 2019 Feb 4;218(2):683-699. Epub 2018 Nov 23.

DOI: 10.1083/jcb.201802008.

An Inactivation Switch Enables Rhythms in a Neurospora Clock Model.

Upadhyay, A., Brunner, M., Herzel, H. (2019).

Int. J. Mol. Sci., 20(12), 2985.

DOI: 10.3390/ijms20122985.

A missing switch in peptide exchange for MHC class II molecules.

Freund, C. & Höfer, T. (2019).

Front. Immunol.

DOI: 10.3389/fimmu.2019.02513.

3D cellular architecture modulates tyrosine kinase activ- ity thereby switching CD95 mediated apoptosis to survival.

Gülcüler Balta, G. S., Monzel, C., Kleber, S., Beaudouin, J., Balta, E., Kaindl, T., Chen, S., Gao, L., Thiemann, M., Wirtz, C. R., Samstag, Y., Tanaka, M., Martin-Villalba, A. (2019).

Cell Reports (in press).

Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line.

Hauke, S., Dutta, A. K., Eisenbeis, V. B., Bezold, D., Bittner, T., Wittwer, C., Thakor, D., Pavlovic, I., Schultz, C., Jessen, H. J. (2019).

Chem. Sci. 10:2687-2692.

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress.

Höglinger, D., Burgoyne, T., Sanchez-Heras, E., Hartwig, P., Colaco, A., Newton, J., Futter, C., Spiegel, S., Platt, F., Eden, E. (2019).

Nat Commun, 10(1):4276-4289.

Bi- and Trifunctional Lipids for Visualization of Sphingolipid Dynamics within the Cell.

Höglinger, D. (2019).

Methods Mol Biol, 1949:95-103.

Illuminating G-Protein-Coupling Selectivity of GPCRs.

Inoue, A., Raimondi, F., Kadji, F. M. N., Singh, G., Kishi, T., Uwamizu, A., Ono, Y., Shinjo, Y., Ishida, S., Arang, N., Kawakami, K., Gutkind, J. S., Aoki, J., Russell, R. B. (2019).

Methods Mol Biol, 1949:95-103.

Onset of differentiation is posttranscriptionally controlled in adult neural stem cells.

Baser, A., Skabkin, M., Kleber, S., Dang, Y., Gülcüler Balta, G. S., Kalamakis, G., Göpferich, M., Ibañez, D. C., Schefzik, R., Lopez, A. S., Bobadilla, E. L., Schultz, C., Fischer, B., Martin-Villalba, A. (2019).

Nature 566:100-104.

Photo-release of 2-arachidonoylglycerol in live cells.

Laguerre, A., Hauke, S., Qiu, J., Kelly, M., Schultz, C. (2019).

J. Am. Chem. Soc. 141, 16544-16547.

Nanoscale coupling of endocytic pit growth and stability.

Lehmann, M., Lukonin, I., Noé, F., Schmoranzer, J., Clementi, C., Loerke, D., Haucke, V. (2019).

Sci Adv. 2019 Nov 27;5(11):eaax5775. eCollection 2019 Nov.

DOI: 10.1074/jbc.RA119.011774.

Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes.

Müksch, F., Cetir, M., Lüchtenborg, C., Glass, B., Traynor-Kaplan, A., Schultz, C., Brügger, B., Kräusslich, H. G. (2019).

Sci Reports, 9(1):17661.

DOI: 10.1038/s41598-019-53939-z.

Synthesis and cellular labeling of caged phosphatidylinositol derivatives.

Müller, R., Citir, M., Hauke, S., Schultz, C. (2019).

Chemistry.

DOI: 10.1002/chem.201903704.

Hypoxic environment promotes barrier formation in human intestinal epithelial cells through regulation of miRNA-320a expression.

Muenchau, S., Deutsch, R., de Castro, I. J., Hielscher, T., Heber, N., Niesler, B., Lusic, M., Stanifer, M. L., Boulant S. (2019).

Mol Cell Biol. 39(14). pii: e00553-18.

Dynamic graphical models of molecular kinetics.

Olsson, S., Noé F. (2019).

Proc. Natl. Acad. Sci. USA. 116(30): 15001-15006.

Serial synapse formation through filopodial competition for synaptic seeding factors.

Ozel, M. N., Kulkarni, A., Hasan, A., Brummer, J., Moldenhauer, M., Daumann, I. M., Wolfenberg, H., Dercksen, V. J., Kiral, F. R., Weiser, M., Prohaska, S., von Kleist, M., Hiesinger, P. R. (2019).

Dev Cell, 50(4):447-461.

Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis.

Poulsen, M. H., Poshtiban, A., Klippenstein, V., Ghisi. V, and Plested, A. J. R. (2019).

Proc Natl Acad Sci USA 116(27):13358-13367.

Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

Quade, B., Camacho, M., Zhao, X., Orlando, M., Trimbuch, T., Xu, J., Li, W., Nicastro, D., Rosenmund, C., and Rizo, J. (2019).

Elife 8, e42806

Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells.

Stanifer, M., Mukenhirn, M,. Muenchau, S., Pervolaraki, K., Kanaya, T., Albrecht, D., Haucke, V., Odendall, C., Ka- gan, J. C., Bartfeld, S., Ohno, H., and Boulant, S. (2019).

Nature Microbiology.

https://www.nature.com/articles/s41564-019-0594-3

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signaling via mTORC1.

Wallroth, A., Koch, P. A., Marat, A. L., Krause, E., Haucke, V. (2019).

Nat Cell Biol 21: 1093-1101.

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.

Wang, H., Loerke, D., Bruns, C., Müller, R., Koch, P. A., Puchkov, D., Schultz, C., Haucke, V. (2019).

J Biol Chem. 2019 Dec 12. pii: jbc.RA119.011774.

DOI: 10.1074/jbc.RA119.011774.

Mechanical signals regulate TORC2 activity.

Ebner, M., Haucke, V. (2018).

Nat. Cell Biol. 20: 994-995 (News and Views).

Quantitative analysis of circadian single cell oscillations in response to temperature

Abraham, U., Schlichting, J. K., Kramer, A., Herzel, H. (2018).

PLoS One. 2018 Jan 2;13(1):e0190004.

DOI: 10.1371/journal.pone.0190004.

Ultradian Rhythms in the Transcriptome of Neurospora crassa.

Ananthasubramaniam, B., Diernfellner, A., Brunner, M., Herzel, H. (2018).

iScience. 2018 Nov 30;9:475-486. Epub 2018 Nov 10.

DOI: 10.1016/j.isci.2018.11.012.

Regulation of synaptic release-site-Ca2+-channel coupling as a mechanism to control release probability and short-term plasticity

Bohme, M. A., Grasskamp, A. T., and Walter, A. M. (2018).

FEBS Lett. 2018 Nov;592(21):3516-3531. Epub 2018 Jul 31.

DOI: 10.1002/1873-3468.13188.

Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment.

Chang, S., Trimbuch, T., Rosenmund, C(2018).

Nat Neurosci. 2018 Jan;21(1):33-40. Epub 2017 Dec 11.

DOI: 10.1038/s41593-017-0037-5.

Unconventional mechanisms of eukaryotic protein secretion.

Dimou, E., Nickel, W. (2018).

Curr Biol. 2018 Apr 23;28(8):R406-R410.

DOI: 10.1016/j.cub.2017.11.074.

Open-source recombinant monoclonal secondary nanobodies.

Ewers, H. (2018).

J Cell Biol. 2018 Mar 5;217(3):809-811. Epub 2018 Feb 14.

DOI: 10.1083/jcb.201802025.

Optical tools for understanding the complexity of beta cell signaling and insulin release.

Frank, J., Broichhagen, J., Yushchenko, D., Trauner, D., Schultz, C., Hodson, D. (2018).

Nat Rev Endocrinol. 2018 Dec;14(12):721-737.

DOI: 10.1038/s41574-018-0105-2.

Surface Immobilization of Viruses and Nanoparticles Elucidates Early Events in Clathrin-mediated Endocytosis.

Fratini, M., Wiegand, T., Funaya, C., Spatz, J. P., Cavalcanti-Adam, E. A., Boulant, S. (2018).

ACS Infect Dis. 2018 Nov 9;4(11):1585-1600. Epub 2018 Sep 26.

DOI: 10.1021/acsinfecdis.8b00134.

Expansion Stimulated Emission Depletion Microscopy (ExSTED).

Gao, M., Maraspini, R., Beutel, O., Zehtabian, A., Eickholt, B., Honigmann, A., Ewers, H. (2018).

ACS Nano. 2018 May 22;12(5):4178-4185. Epub 2018 Apr 19.

DOI: 10.1021/acsnano.8b00776.

Endogenous Fatty Acids are Essential Autocrine Signaling Factors of Pancreatic β-Cells and Insulin Secretion.

Hauke, S., Keutler, K., Phapale, P., Yushchenko, D., Schultz, C. (2018).

Diabetes. 2018 Oct;67(10):1986-1998.

DOI: doi.org/10.2337/db17-1215.

The Evolution of Variability and Robustness in Neural Development.

Hiesinger, P. R., Hassan, B. A. (2018).

Trends in Neuroscience 41(9):577-586.

DOI: 10.1016/j.tins.2018.05.007.

The where, what, and when of membrane protein degradation in neurons.

Jin, E. J., Kiral, F. R., Hiesinger, P. R. (2018).

Dev Neurobiol. 2018 Mar;78(3):283-297. Epub 2017 Sep 19. Review.

DOI: 10.1002/dneu.22534.

Live observation of two parallel membrane degradation pathways at axon terminals.

Jin, E. J., Kiral, F. R., Özel, M. N., Burchardt, L. S., Osterland, M., Epstein, D., Wolfenberg, H., Prohaska, S., Hiesinger, P. R. (2018).

Curr. Biol., 28(7):1027-1038.e4.

DOI: 10.1016/j.cub.2018.02.032.

PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.

Kath, C., Goni-Oliver, P., Müller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J. (2018).

PLoS One 13, e0193257. 

DOI: 10.1371/journal.pone.0193257.

Unconventional secretion mediates the trans-cellular spreading of tau.

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