Publications

Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment.

Chang S, Trimbuch T, Rosenmund C.

Nat Neurosci. 2018 Jan;21(1):33-40. doi: 10.1038/s41593-017-0037-5. Epub 2017 Dec 11.

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

Walter AM, Müller R, Tawfik B, Wierda KD, Pinheiro PS, Nadler A, McCarthy AW, Ziomkiewicz I, Kruse M, Reither G, Rettig J, Lehmann M, Haucke V, Hille B, Schultz C, Sorensen JB.

Elife. 2017 Oct 25;6. pii: e30203. doi: 10.7554/eLife.30203.

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.

Piwecka M, Glažar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, Filipchyk A, Klironomos F, Cerda Jara CA, Fenske P, Trimbuch T, Zywitza V, Plass M, Schreyer L, Ayoub S, Kocks C, Kühn R, Rosenmund C, Birchmeier C, Rajewsky N.

Science. 2017 Sep 22;357(6357). pii: eaam8526. doi: 10.1126/science.aam8526. Epub 2017 Aug 10.

Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Reddy-Alla S, Böhme MA, Reynolds E, Beis C, Grasskamp AT, Mampell MM, Maglione M, Jusyte M, Rey U, Babikir H, McCarthy AW, Quentin C, Matkovic T, Bergeron DD, Mushtaq Z, Göttfert F, Owald D, Mielke T, Hell SW, Sigrist SJWalter AM.

Neuron. 2017 Sep 13;95(6):1350-1364.e12. doi: 10.1016/j.neuron.2017.08.016. Epub 2017 Aug 31.

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components.

Steringer JP, Lange S, Čujová S, Šachl R, Poojari C, Lolicato F, Beutel O, Müller HM, Unger S, Coskun Ü, Honigmann A, Vattulainen I, Hof M, Freund C, Nickel W.

Elife. 2017 Jul 19;6. pii: e28985. doi: 10.7554/eLife.28985

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.

Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, Melchior F, Deshaies RJ, Brunner M, Diernfellner A.

Nat Chem Biol. 2017 Jul;13(7):709-714. doi: 10.1038/nchembio.2370. Epub 2017 May 1.

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.

Marat AL, Wallroth A, Lo WT, Müller R, Norata GD, Falasca M, Schultz C, Haucke V.

Science. 2017 Jun 2;356(6341):968-972. doi: 10.1126/science.aaf8310.

 

Principles for circadian orchestration of metabolic pathways.

Thurley K, Herbst C, Wesener F, Koller B, Wallach T, Maier B, Kramer A, Westermark PO.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1572-1577

A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells

Schifferer, M., Yushchenko, D. A., Hodson, D. J., Bolbat, A., Stein, F., Schultz, C.

Cell Chem. Biol. 24, 525-531 (2017).

Reciprocal regulation of carbon monoxide metabolism and the circadian clock.

Klemz R, Reischl S, Wallach T, Witte N, Jürchott K, Klemz S, Lang V, Lorenzen S, Knauer M, Heidenreich S, Xu M, Ripperger JA, Schupp M, Stanewsky R, Kramer A.

Nat Struct Mol Biol. 2017 Jan;24(1):15-22

Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2.

La Venuta G, Wegehingel S, Sehr P, Müller HM, Dimou E, Steringer JP, Grotwinkel M, Hentze N, Mayer MP, Will DW, Uhrig U, Lewis JD, Nickel W.

J Biol Chem. 2016 Aug 19;291(34):17787-803. doi: 10.1074/jbc.M116.729384. Epub 2016 Jul 5.

Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator.

Pett JP, Korenčič A, Wesener F, Kramer A, Herzel H.

PLoS Comput Biol. 2016 Dec 12;12(12):e1005266.