Dr. Eva Absmeier
Freie Universität Berlin
Institut für Chemie und Biochemie
Takustraße 6
14195 Berlin
Phone: +49 (30) 838 50508
E-mail: eva.absmeier@fu-berlin.de
Research Area
Structural biochemistry
Position and Status
CRC-associated junior group leader
Scholarships and awards
2019 – 2022 German Research Foundation PostDoc Fellowship
2016 DAAD travel fellowship; 21st Annual Meeting of the RNA Society, Kyoto, Japan
2015 FEBS Young Scientists’ Forum Attendance Grant; The 40th FEBS Congress, Berlin, Germany
2015 Best Poster Award; 50th Winter Seminar, Biophysical Chemistry, Molecular Biology and Cybernetics of Cell Functions, Klosters, Switzerland
2015 Travel fellowship, IRI Graduate School; 50th Winter Seminar, Biophysical Chemistry, Molecular Biology and Cybernetics of Cell Functions, Klosters, Switzerland
2014 Women promotion travel fellowship, Freie Universität Berlin; 19th Annual Meeting of the RNA Society, Quebec, Canada
University training and degree
2008 - 2010: Master of Science, Technische Universität München, Munich, Germany
2005 - 2008: Bachelor of Science, Technische Universität München, Munich, Germany
Advanced academic qualifications
2011 - 2016 Doctoral researcher in the group of Markus C Wahl at the Freie Universität Berlin, Berlin, Germany
Postgraduate professional career
Since 05/2023: SFB/CRC-associated group leader at the Freie Universität Berlin, institute for chemistry and biochemistry, Berlin, Germany
2019 - 2023: Post-doctoral researcher in the group of Lori Passmore at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB), Cambridge, United Kingdom
2016 - 2019: Post-doctoral researcher in the group of Markus C Wahl at the Freie Universität Berlin, Berlin, Germany
2019 Session Chair of the 1st UCSF-Berlin Integrative Structural Biology Meeting, Berlin, Germany
2019 Tour participant at the Berlin University Alliance for the Universities of Excellence Funding Line Germany, Berlin, Germany
2018 – 2019 Member of PhD Examination Committees, Freie Universität Berlin, Germany
2018 Session Chair of the 3rd International Symposium “Membranes and Modules”, Berlin, Germany
2018 Member of the Search Committee, W3 Professorship for RNA Biochemistry, Freie Universität, Berlin, Germany
2015 Member of the Organization Committee and Chair of the RNA Symposium, IRI Graduate School, Berlin, Germany
1 Absmeier, E., Chandrasekaran, V., O’Reilly, F. J., Stowell, J. A. W., Rappsilber, J. & Passmore, L. A. Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT. Nature Structural & Molecular Biology 30, 1314-1322 (2023). https://doi.org/10.1038/s41594-023-01075-8
2 Höpfler, M., Absmeier, E., Peak-Chew, S.-Y., Vartholomaiou, E., Passmore, L. A., Gasic, I. & Hegde, R. S. Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation. Molecular Cell 83, 2290-2302.e2213 (2023). https://doi.org/10.1016/j.molcel.2023.05.020
3 Absmeier, E., Vester, K., Ghane, T., Burakovskiy, D., Milon, P., Imhof, P., Rodnina, M. V., Santos, K. F. & Wahl, M. C. Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. Journal of Biological Chemistry 297, 100829 (2021). https://doi.org/10.1016/j.jbc.2021.100829
4 Jia, J., Absmeier, E., Holton, N., Pietrzyk-Brzezinska, A. J., Hackert, P., Bohnsack, K. E., Bohnsack, M. T. & Wahl, M. C. The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. Nature Communications 11, 5535 (2020). https://doi.org/10.1038/s41467-020-19221-x
5 Jia, J., Ganichkin, O. M., Preußner, M., Absmeier, E., Alings, C., Loll, B., Heyd, F. & Wahl, M. C. A Snu114–GTP–Prp8 module forms a relay station for efficient splicing in yeast. Nucleic Acids Research 48, 4572-4584 (2020). https://doi.org/10.1093/nar/gkaa182
6 Absmeier, E., Santos, K. F. & Wahl, M. C. Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase. Structure 28, 236-243.e233 (2020). https://doi.org/10.1016/j.str.2019.11.014
7 Pietrzyk-Brzezinska, A. J., Absmeier, E., Klauck, E., Wen, Y., Antelmann, H. & Wahl, M. C. Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB. Structure 26, 1462-1473.e1464 (2018). https://doi.org/10.1016/j.str.2018.07.013
8 Absmeier, E., Becke, C., Wollenhaupt, J., Santos, K. F. & Wahl, M. C. Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle 16, 100-112 (2017). https://doi.org/10.1080/15384101.2016.1255384
9 Absmeier, E., Wollenhaupt, J., Mozaffari-Jovin, S., Becke, C., Lee, C.-T., Preussner, M., Heyd, F., Urlaub, H., Lührmann, R., Santos, K. F. & Wahl, M. C. The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes & Development (2015). http://www.genesdev.org/cgi/doi/10.1101/gad.271528.115
10 Absmeier, E., Rosenberger, L., Apelt, L., Becke, C., Santos, K. F., Stelzl, U. & Wahl, M. C. A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein. Acta Crystallographica Section D 71, 762-771 (2015). https://doi.org/10.1107/S1399004715001005