Dr. Eva Absmeier
Freie Universität Berlin
Institut für Chemie und Biochemie
Takustraße 6
14195 Berlin
Phone: +49 (30) 838 50508
E-mail: eva.absmeier@fu-berlin.de
Position and Status
Group Leader
University training and degree
2008 - 2010: Master of Science, Technische Universität München, Munich, Germany
2005 - 2008: Bachelor of Science, Technische Universität München, Munich, Germany
Advanced academic qualifications
2011 - 2016 Doctoral researcher in the group of Markus C Wahl at the Freie Universität Berlin, Berlin, Germany
Postgraduate professional career
Since 05/2023: SFB/CRC-associated group leader at the Freie Universität Berlin, institute for chemistry and biochemistry, Berlin, Germany
2019 - 2023: Post-doctoral researcher in the group of Lori Passmore at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB), Cambridge, United Kingdom
2016 - 2019: Post-doctoral researcher in the group of Markus C Wahl at the Freie Universität Berlin, Berlin, Germany
1 Absmeier, E., Chandrasekaran, V., O’Reilly, F. J., Stowell, J. A. W., Rappsilber, J. & Passmore, L. A. Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT. Nature Structural & Molecular Biology 30, 1314-1322 (2023).
2 Höpfler, M., Absmeier, E., Peak-Chew, S.-Y., Vartholomaiou, E., Passmore, L. A., Gasic, I. & Hegde, R. S. Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation. Molecular Cell 83, 2290-2302.e2213 (2023).
3 Absmeier, E., Vester, K., Ghane, T., Burakovskiy, D., Milon, P., Imhof, P., Rodnina, M. V., Santos, K. F. & Wahl, M. C. Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. Journal of Biological Chemistry 297, 100829 (2021).
4 Jia, J., Absmeier, E., Holton, N., Pietrzyk-Brzezinska, A. J., Hackert, P., Bohnsack, K. E., Bohnsack, M. T. & Wahl, M. C. The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. Nature Communications 11, 5535 (2020).
5 Jia, J., Ganichkin, O. M., Preußner, M., Absmeier, E., Alings, C., Loll, B., Heyd, F. & Wahl, M. C. A Snu114–GTP–Prp8 module forms a relay station for efficient splicing in yeast. Nucleic Acids Research 48, 4572-4584 (2020).
6 Absmeier, E., Santos, K. F. & Wahl, M. C. Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase. Structure 28, 236-243.e233 (2020).
7 Pietrzyk-Brzezinska, A. J., Absmeier, E., Klauck, E., Wen, Y., Antelmann, H. & Wahl, M. C. Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB. Structure 26, 1462-1473.e1464 (2018).
8 Absmeier, E., Becke, C., Wollenhaupt, J., Santos, K. F. & Wahl, M. C. Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle 16, 100-112 (2017).
9 Absmeier, E., Wollenhaupt, J., Mozaffari-Jovin, S., Becke, C., Lee, C.-T., Preussner, M., Heyd, F., Urlaub, H., Lührmann, R., Santos, K. F. & Wahl, M. C. The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes & Development (2015).
10 Absmeier, E., Rosenberger, L., Apelt, L., Becke, C., Santos, K. F., Stelzl, U. & Wahl, M. C. A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein. Acta Crystallographica Section D 71, 762-771 (2015).