Spatio-temporal control of FGF2 recruitment and membrane translocation exerted by phosphoinositide and kinase switches

Prof. Dr. Walter Nickel (BZH Heidelberg)
Prof. Dr. Helge Ewers (FU Berlin)

Acute control of intracellular trafficking through Rab GTPases in living tissues in Drosophila
Prof. Dr. Michael Boutros (Med. Fakultät Mannheim/Heidelberg)
Prof. Dr. P. Robin Hiesinger (FU Berlin)

Ca2+ and lipid control of vesicle fusion in ß-cells and neurons

Prof. Dr. Stephan Sigrist (FU Berlin)
PD Dr. Carsten Schultz (EMBL Heidelberg)
Dr. Alexander M. Walter (FMP Berlin)

Neurotransmitter release: Spatio-temporal characterization of membrane fusion intermediates

Prof. Dr. Thomas Söllner (BZH Heidelberg)
Prof. Dr. Christian Rosenmund (Charité Berlin)

The palmitoylation switch in activated T cells

Prof. Dr. Christian Freund (FU Berlin)
Prof. Dr. Britta Brügger (BZH Heidelberg)

Spatio-temporal control of CD95-activation mode

Prof. Dr. Ana Martin-Villalba (DKFZ Heidelberg)
Prof. Dr. Helge Ewers (FU Berlin)

Optical control of calcium switches that orchestrate fast signaling in the brain

Dr. Andrew Plested (FMP Berlin)
Prof. Dr. Peter Hegemann (HU Berlin)

Phosphoinositide-based switches in endocytic membrane traffic and signaling

Prof. Dr. Volker Haucke (FMP Berlin)
PD. Dr. Carsten Schultz (EMBL Heidelberg)

Phosphoinositide-based switches in polarized sorting and signaling

Dr. Steeve Boulant (Med. Fakultät Heidelberg)
Prof. Dr. Volker Haucke (FMP Berlin)

Switching plasma membrane phosphoinositide compositions in neurons: Implications for membrane dynamics, axonal morphogenesis and the cortical actin cytoskeleton

Prof. Dr. Britta Eickholt (Charité Berlin)

Systematic characterization of phosphoinositide switches involved in T cell function

Dr. Anne-Claude Gavin (EMBL Heidelberg)
Prof. Dr. Christian Freund (FU Berlin)
Prof. Dr. Robert B. Russell (BZH Heidelberg)

Effect of membrane lipid phosphorylation on protein recruitment at molecular and cellular scales

Prof. Dr. Frank Noé (FU Berlin)
Dr. Nuria Plattner (FU Berlin)

Elucidating the redox-proteolysis switch for transcriptional induction of the ubiquitin proteasome system in space and time
Prof. Dr. Elke Krüger (UM Greifswald)

Molecular switches regulating stress granule oscillation
Dr. Alessia Ruggieri (Med. Fakultät Heidelberg)
Prof. Dr. Georg Stoecklin (Med. Fakultät Mannheim / Heidelberg)

Temporal control of spliceosome activity to modulate splicing switches during T cell activation and serum stimulation

Prof. Dr. Florian Heyd (FU Berlin)
Prof. Dr. Markus Wahl (FU Berlin)

Functional characterization of the molecular timer of the circadian clock of Neurospora crassa

Prof. Dr. Michael Brunner (BZH Heidelberg)
Prof. Dr. Hans-Peter Herzel (Charité Berlin)

Chemical control of PER2-CRY1 heterodimerization: impact on circadian oscillations

Prof. Dr. Achim Kramer (Charité Berlin)
Prof. Dr. Hans-Peter Herzel (Charité Berlin)

A SUMO switch in EGF receptor signaling

Prof. Dr. Frauke Melchior (ZMBH Heidelberg)

Molecular tools for fast switching of cellular events

PD. Dr. Carsten Schultz (EMBL Heidelberg)

Quantitative Image Processing

Prof. Dr. Helge Ewers (FU Berlin)

Associated Projects

Bottanelli Group
Nanoscale regulation of molecular switches at the Golgi)

Prof. Dr. Francesca Bottanelli (FU Berlin)

Höglinger Group
A lipid switch at organelle contact sites

Dr. Doris Höglinger (BZH Heidelberg)