Prof. Dr. Tobias Dick

Tobias Dick

Deutsches Krebsforschungszentrum (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg
Phone: +49 (6221) 42-2320
E-mail: t.dick@dkfz.de



Position and Status

Department Head


Scholarships and awards

2019 Highly Cited Researcher 2019 (Cross-Field) - Web of Science (Clarivate)

2017 - ERC Advanced Grant
2017 - Society for Free Radical Research Europe Basic Science Award
2009 - Chica- and Heinz-Schaller-Award for young scientists
2004 - Marie Curie Excellence Grant
1998 - 2000 -  Postdoctoral fellowship from the German Research Council (DFG)
1989 - 1994 - Scholarship from the 'Studienstiftung des Deutschen Volkes'



University training and degree

1994 - Diploma thesis with Hans-Georg Rammensee at the German Cancer Research Center, Heidelberg
1989 - 1994 - Study program in Biochemistry, Freie Universität Berlin

 

Advanced academic qualifications

2009 - Habilitation in Biochemistry, Faculty of Biosciences, Heidelberg University
1997 - PhD (Dr. rer. nat.) in Biochemistry, FU Berlin (summa cum laude); carried out in the laboratory of Hans-Georg Rammensee (German Cancer Research Center, Heidelberg and Institute for Immunology, University of Tübingen)

 

Postgraduate professional career

2010 - Head of Divison 'Redox Regulation', German Cancer Research Center, Heidelberg
2003 - 2009 - Independent Junior Group Leader, German Cancer Research Center, Heidelberg
1998 - 2002 - Postdoctoral Researcher, Howard Hughes Medical Institute, Yale University, New Haven, USA

Coordinating functions and editorial work

2012 – present DKFZ representative and contact person for the “German Society for Biochemistry and Molecular Biology” (GBM)

2020 – 2022 Coordinator of DFG priority program SPP1710 “Dynamics of Thiol-Based Redox Switches in Cellular Physiology”

2014 - 2019 - Co-founder and vice coordinator of the DFG-funded priority program SPP1710 “Dynamics of Thiol-Based Redox Switches in Cellular Physiology”
2011 - 2017 - Co-founder and vice coordinator of the Study Group ‘Redox Biology’ within the “German Society for Biochemistry and Molecular Biology” (GBM)

Most important publications

  1. Talwar, D., Miller, C. G., Grossmann, J., Szyrwiel, L., Schwecke, T., Demichev, V., Mikecin Drazic, A.-M., Mayakonda, A., Lutsik, P., Veith, C., Milsom, M. D., Müller-Decker, K., Mülleder, M., Ralser, M. & Dick, T. P. The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells. Nature Metabolism 5, 660-676 (2023). https://doi.org/10.1038/s42255-023-00781-3

  2. Barayeu, U., Schilling, D., Eid, M., Xavier da Silva, T. N., Schlicker, L., Mitreska, N., Zapp, C., Gräter, F., Miller, A. K., Kappl, R., Schulze, A., Friedmann Angeli, J. P. & Dick, T. P. Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals. Nature Chemical Biology 19, 28-37 (2023). https://doi.org/10.1038/s41589-022-01145-w

  3. Stöcker, S., Maurer, M., Ruppert, T. & Dick, T. P. A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation. Nature Chemical Biology 14, 148-155 (2018). https://doi.org/10.1038/nchembio.2536
  4. Morgan, B., Van Laer, K., Owusu, T. N. E., Ezeriņa, D., Pastor-Flores, D., Amponsah, P. S., Tursch, A. & Dick, T. P. Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes. Nature Chemical Biology 12, 437-443 (2016). https://doi.org/10.1038/nchembio.2067
  5. Peralta, D., Bronowska, A. K., Morgan, B., Dóka, É., Van Laer, K., Nagy, P., Gräter, F. & Dick, T. P. A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nature Chemical Biology 11, 156-163 (2015). https://doi.org/10.1038/nchembio.1720
  6. Sobotta, M. C., Liou, W., Stöcker, S., Talwar, D., Oehler, M., Ruppert, T., Scharf, A. N. D. & Dick, T. P. Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nature Chemical Biology 11, 64-70 (2015).  https://doi.org/10.1038/nchembio.1695
  7. Morgan, B., Ezeriņa, D., Amoako, T. N. E., Riemer, J., Seedorf, M. & Dick, T. P. Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nature Chemical Biology 9, 119-125 (2013). https://doi.org/10.1038/nchembio.1142
  8. Albrecht, Simone C., Barata, Ana G., Großhans, J., Teleman, Aurelio A. & Dick, Tobias P. In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis. Cell Metabolism 14, 819-829 (2011). DOI: 10.1016/j.cmet.2011.10.010
  9. Gutscher, M., Pauleau, A.-L., Marty, L., Brach, T., Wabnitz, G. H., Samstag, Y., Meyer, A. J. & Dick, T. P. Real-time imaging of the intracellular glutathione redox potential. Nature Methods 5, 553-559 (2008). https://doi.org/10.1038/nmeth.1212
  10. Kienast, A., Preuss, M., Winkler, M. & Dick, T. P. Redox regulation of peptide receptivity of major histocompatibility complex class I molecules by ERp57 and tapasin. Nature Immunology 8, 864-872 (2007). https://doi.org/10.1038/ni1483