Prof. Dr. Stephan Sigrist


Freie Universität Berlin
Institut für Biologie
Takustr. 6
14195 Berlin
Phone: +49 (30) 8385 6940

Research Area

Biochemistry, Genetics, Electrophysiology, Imaging

Position and Status

Professor of Biochemistry (W3)

Scholarships and awards

2005               Prize for best habilitation at the Faculty of Medicine, University of Göttingen
2000               EMBO long-term fellowship
2000               Human Frontier Science Program long-term fellowship
1998 - 1999    Scholarship of the Claußenstiftung (“Stifterverband der Deutschen Industrie”)

Academic Education

1988 - 1992   Study of Biochemistry, Universität Tübingen, Diploma, Prof. Dr. Lehner
1986 - 1988   Study of Chemistry, Technische Universität Berlin


University Degrees

2005   Habilitation in Biochemistry, Georg-August University Göttingen, Medical Faculty
1997   PhD in Biology, University of Tübingen, Prof. Dr. C. Lehner



2008 -            Full professor of Biochemistry (W3), FU Berlin and Charité Universitätsmedizin Berlin
2006 - 2008   Professor (W2), Experimental Biomedicine and Bio-Imaging, University of Würzburg
2000 - 2005   Group leader, Independent Max-Planck-Research Group “Neuroplasticity”, European Neuroscience Institute (ENI), Göttingen
1997 - 2000   Postdoctoral fellow, Laboratory of Christoph Schuster, Max-Planck-Institut Tübingen

  1. Muhammad K, Reddy-Alla S, Driller JH, Schreiner D, Rey U, Böhme MA, Hollmann C, Ramesh N, Depner H, Lützkendorf J, Matkovic T, Götz T, Bergeron DD, Schmoranzer J, Goettfert F, Holt M, Wahl MC, Hell SW, Scheiffele P, Walter AM, Loll B, Sigrist SJ (2015) Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Nat. Commun. 6:8632
  2. Gupta, V. K., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S., Schroeder, S., Stunnenberg, H. G., Sinner, F., Magnes, C., Pieber, T. R., Dipt, S., Fiala, A., Schenck, A., Schwaerzel, M., Madeo, F. & Sigrist, S. J. (2013) Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat. Neurosci. 16:1453- 1460.
  3. Owald, D., Khorramshahi, O., Gupta, V. K., Banovic, D., Depner, H., Fouquet, W., Wichmann, C., Mertel, S., Eimer, S., Reynolds, E., Holt, M., Aberle, H. & Sigrist, S. J. (2012) Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. Nat. Neurosci. 15:1219-1226.
  4. Liu, K. S., Siebert, M., Mertel, S., Knoche, E., Wegener, S., Wichmann, C., Matkovic, T., Muhammad, K., Depner, H., Mettke, C., Buckers, J., Hell, S. W., Muller, M., Davis, G. W., Schmitz, D. & Sigrist, S. J. (2011) RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science 334:1565-1569.
  5. Banovic, D., Khorramshahi, O., Owald, D., Wichmann, C., Riedt, T., Fouquet, W., Tian, R., Sigrist, S. J. *& Aberle, H. * (2011) Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions. Neuron 66:724-738. * Correspondence shared
  6. Schmid, A., Hallermann, S., Kittel, R. J., Khorramshahi, O., Frolich, A. M., Quentin, C., Rasse, T. M., Mertel, S., Heckmann, M. & Sigrist, S. J. (2008) Activity-dependent site-specific changes of glutamate receptor composition in vivo. Nat. Neurosci. 11:659-666.
  7. Kittel, R. J., Wichmann, C., Rasse, T. M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D. A., Pawlu, C., Kellner, R. R., Willig, K. I., Hell, S. W., Buchner, E., Heckmann, M. & Sigrist, S. J. (2006) Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release. Science 312:1051-1054.
  8. Rasse, T. M., Fouquet, W., Schmid, A., Kittel, R. J., Mertel, S., Sigrist, C. B., Schmidt, M., Guzman, A., Merino, C., Qin, G., Quentin, C., Madeo, F., Heckmann, M. & Sigrist, S. J. (2005) Glutamate receptor dynamics organizing synapse formation in vivo. Nat. Neurosci. 8:898-905.
  9. Sigrist, S. J., Thiel, P. R., Reiff, D. F., Lachance, P. E., Lasko, P. & Schuster, C. M. (2000) Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature 405:1062-1065.
  10. Sigrist, S. J. & Lehner, C. F. (1997) Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90:671-681.