Prof. Dr. Stephan Sigrist


Freie Universität Berlin
Institut für Biologie
Takustr. 6
14195 Berlin
Phone: +49 (30) 8385 6940

Position and Status

Full Professor of Biochemistry (W3)

Scholarships and awards

2014 - present -  Einstein Professorship of the Einstein Foundation Berlin, Germany
2005 - Best Habilitation Award awarded by the University Medical Center Göttingen, Georg-August-Universität Göttingen, Germany
2000 - EMBO Long-term Fellowship: Funding of Postdoc position by European Molecular Biology Organization Heidelberg, Germany
2000 - HFSP Long-term Fellowship: Funding of Postdoc position, Long-term Fellowship Human Frontier Science Program Organization Strasbourg, France

University training and degree

1988 - 1992 - Study of Biochemistry, Universität Tübingen, Diploma, Prof. Dr. Lehner
1986 - 1988 - Study of Chemistry, Technische Universität Berlin


Advanced academic education

2005 Habilitation in Biochemistry, Georg-August University Göttingen, Medical Faculty
1997 PhD in Biology, University of Tübingen, Prof. Dr. C. Lehner


Postgraduate professional career

2008 - present - Full professor of Biochemistry (W3), FU Berlin and Charité Universitätsmedizin Berlin
2006 - 2008 - Professor (W2), Experimental Biomedicine and Bio-Imaging, University of Würzburg
2000 - 2005 - Group leader, Independent Max-Planck-Research Group “Neuroplasticity”, European Neuroscience Institute (ENI), Göttingen
1997 - 2000 - Postdoctoral fellow, Laboratory of Christoph Schuster, Max-Planck-Institut Tübingen

Most important publications

  1. Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. Bhukel A, Beuschel CB, Maglione M, Lehmann M, Juhász G, Madeo F, Sigrist SJNat Commun. 10(1), 2019 Mar 21;10(1):1318.

  2. Vukoja, A., Rey, U., Petzoldt, A.G., Ott, C., Vollweiter, D., Quentin, C., Puchkov, D., Reynolds, E., Lehmann, M., Hohensee, S., Rosa, S., Lipowsky, R., Sigrist, S.J., Haucke, V. (2018) Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles. Neuron. 99:1216-1232.e7

  3. Reddy-Alla, S., Bohme, M.A., Reynolds, E., Beis, C., Grasskamp, A.T., Mampell, M.M., Maglione, M., Jusyte, M., Rey, U., Babikir, H., McCarthy, A.W., Quentin, C., Matkovic, T., Bergeron, D.D., Mushtaq, Z., Gottfert, F., Owald, D., Mielke, T., Hell, S.W., Sigrist, S.J., Walter, A.M. (2017) Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission. Neuron. 95:1350-1364 e1312

  4. Bohme, M.A., Beis, C., Reddy-Alla, S., Reynolds, E., Mampell, M.M., Grasskamp, A.T., Lutzkendorf, J., Bergeron, D.D., Driller, J.H., Babikir, H., Gottfert, F., Robinson, I.M., O'Kane, C.J., Hell, S.W., Wahl, M.C., Stelzl, U., Loll, B., Walter, A.M., Sigrist, S.J. (2016) Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling. Nature neuroscience. 19:1311-1320

  5. Gupta, V.K., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T.S., Kramer, J.M., Liu, K.S., Schroeder, S., Stunnenberg, H.G., Sinner, F., Magnes, C., Pieber, T.R., Dipt, S., Fiala, A., Schenck, A., Schwaerzel, M., Madeo, F., Sigrist, S.J. (2013) Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nature neuroscience. 16:1453-1460

  6. Owald, D., Khorramshahi, O., Gupta, V.K., Banovic, D., Depner, H., Fouquet, W., Wichmann, C., Mertel, S., Eimer, S., Reynolds, E., Holt, M., Aberle, H., Sigrist, S.J. (2012) Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. Nature neuroscience. 15:1219-1226

  7. Liu, K.S., Siebert, M., Mertel, S., Knoche, E., Wegener, S., Wichmann, C., Matkovic, T., Muhammad, K., Depner, H., Mettke, C., Buckers, J., Hell, S.W., Muller, M., Davis, G.W., Schmitz, D., Sigrist, S.J. (2011) RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science. 334:1565-1569

  8. Kittel, R.J., Wichmann, C., Rasse, T.M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D.A., Pawlu, C., Kellner, R.R., Willig, K.I. Hell, S.W., Buchner, E., Heckmann, M., Sigrist, S.J. (2006) Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release. Science. 312:1051-1054

  9. Sigrist, S.J., Thiel, P.R., Reiff, D.F., Lachance, P.E., Lasko, P., Schuster, C.M. (2000) Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature. 405:1062-1065

  10. Sigrist, S.J., Lehner, C.F. (1997) Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell. 90:671-681