Prof. Dr. Helge Ewers

Prof. Dr. Helge Ewers

Freie Universität Berlin
Institut für Chemie und Biochemie
Thielallee 63
14195 Berlin
Phone: +49 (30) 838 60644
E-Mail: Helge.Ewers@fu-berlin.de


Research Area

Membrane Biochemistry 


Position and Status

Professor of Membrane Biochemistry (W3)


Scholarships and awards

2011 - Holcim Foundation Fellowship
2011 - Pfizer Research Prize
2008 - Hans-Heinrich-Niemann Prize for Dissertation
2007 - FEBS Long-Term Fellowship, SNF Fellowship (declined)



University training and degree

06/2002 - 03/2003 - Diploma thesis with Bettina Winckler at Mount Sinaii School of Medicine, New York, NY, USA
10/1997 - 06/2002 - Study of Biochemistry at Universität Hannover

 

Advanced academic qualifications

04/2007 - Dr. sc. in Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland, Mentor: Ari Helenius

 

Postgraduate Professional career

11/2014 – present - Professor of Membrane Biochemistry at Institute for Chemistry and Biochemistry, Freie Universität Berlin
06/2017 – present - Leader of Common Research Group for Soft X-Ray Microscopy, HZB
10/2013 – 10/2014 - Senior Lecturer in Cell Biology at the Randall Division of Cell and Molecular Biophysics, King’s College London, United Kingdom
06/2009 - 09/2013 - Group leader at ETH Zürich, Switzerland
09/2007 - 05/2009 - Post-doctoral research fellow with Daniel Choquet at CNRS UMR 5091, Bordeaux, France

Coordinating functions and editorial work

Ongoing -  Ad-hoc grant reviewer for ERC (European Research Council), CZI (Chan Zuckerberg Initiative), DFG (German Research Association), NWO (Dutch scientific society), ANR, FRM (Agence Nationale de Recherche, Fondation Recherche Medicale, France), SNF (Swiss National Fund), MRC (Medical Research Council, UK), BBSRC (Biotechnical and Biological Sciences Research Council, UK), Humboldt foundation

Ongoing - Ad-hoc manuscript reviewer for Nature, Nature Methods, Nature Biotechnology, Nature Communications, Nature Nanotechnology, Nature Photonics, Nature Neuroscience, Nature Protocols, eLife, Journal of Cell Biology, Journal of Cell Science, PNAS, EMBO J, Current Biology, Science Advances, eLife, PLoS Biology, PLoS Pathogens, Biophysical Journal, Langmuir, Angewandte Chemie, JACS, Chemical Reviews, ACS Nano, Nano Letters, Guest editor for PLoS Computational Biolog

2022  - ASAPBio Fellow

2021 - Organiser, EMBO Workshop on Cell and Molecular Biology of Septins, Berlin, (with S. Mostowy and A. Bertin)

Oct 2017 -  Organiser, EMBO Workshop on Cell and Molecular Biology of Septins, Berlin, (with S. Mostowy)

2014 – 2017 - Member, Review Committee, ANR (French Research Agency) Section 11, Biochemistry

2010 – 2018 - Organiser and Founder, Single Molecule Localization Microscopy Symposium (international annual meeting series), scientific committee member (every year), Main organiser: Zürich (2010), Lausanne (2012), London (2014), Berlin (2018)

Most important publications

  1. Dyhr, Michael C. A., Sadeghi, M., Moynova, R., Knappe, C., Kepsutlu Çakmak, B., Werner, S., Schneider, G., McNally, J., Noé, F. & Ewers, H. 3D surface reconstruction of cellular cryo-soft X-ray microscopy tomograms using semisupervised deep learning. Proceedings of the National Academy of Sciences 120, e2209938120 (2023). https://doi.org/10.1073/pnas.2209938120
  2. Thielhorn, R., Heing-Becker, I., Hümpfer, N., Rentsch, J., Haag, R., Licha, K. & Ewers, H. Controlled Grafting Expansion Microscopy. Angewandte Chemie International Edition 62, e202302318 (2023). https://doi.org/10.1002/anie.202302318
  3. Geertsema, H. J., Aimola, G., Fabricius, V., Fuerste, J. P., Kaufer, B. B. & Ewers, H. Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus. Nature Biotechnology 39, 551-554 (2021). https://doi.org/10.1038/s41587-020-00753
  4. Li, J. H., Santos-Otte, P., Au, B., Rentsch, J., Block, S. & Ewers, H. Directed manipulation of membrane proteins by fluorescent magnetic nanoparticles. Nature Communications 11, 4259 (2020). https://doi.org/10.1038/s41467-020-18087-3
  5. Dimou, E., Cosentino, K., Platonova, E., Ros, U., Sadeghi, M., Kashyap, P., Katsinelos, T., Wegehingel, S., Noé, F., García-Sáez, A. J., Ewers, H. & Nickel, W. Single event visualization of unconventional secretion of FGF2. Journal of Cell Biology 218, 683-699 (2018). https://doi.org/10.1083/jcb.201802008
  6. Gao, M., Maraspini, R., Beutel, O., Zehtabian, A., Eickholt, B., Honigmann, A. & Ewers, H. Expansion Stimulated Emission Depletion Microscopy (ExSTED). ACS Nano 12, 4178-4185 (2018). https://doi.org/10.1021/acsnano.8b00776
  7. Albrecht, D., Winterflood, C. M., Sadeghi, M., Tschager, T., Noé, F. & Ewers, H. Nanoscopic compartmentalization of membrane protein motion at the axon initial segment. Journal of Cell Biology 215, 37-46 (2016). https://doi.org/10.1083/jcb.201603108
  8. Mikhaylova, M., Cloin, B. M. C., Finan, K., van den Berg, R., Teeuw, J., Kijanka, M. M., Sokolowski, M., Katrukha, E. A., Maidorn, M., Opazo, F., Moutel, S., Vantard, M., Perez, F., van Bergen en Henegouwen, P. M. P., Hoogenraad, C. C., Ewers, H. & Kapitein, L. C. Resolving bundled microtubules using anti-tubulin nanobodies. Nature Communications 6, 7933 (2015). https://doi.org/10.1038/ncomms8933
  9. Ries, J., Kaplan, C., Platonova, E., Eghlidi, H. & Ewers, H. A simple, versatile method for GFP-based super-resolution microscopy via nanobodies. Nature Methods 9, 582-584 (2012). DOI: 10.1038/nmeth.1991
  10. Ewers, H., Römer, W., Smith, A. E., Bacia, K., Dmitrieff, S., Chai, W., Mancini, R., Kartenbeck, J., Chambon, V., Berland, L., Oppenheim, A., Schwarzmann, G., Feizi, T., Schwille, P., Sens, P., Helenius, A. & Johannes, L. GM1 structure determines SV40-induced membrane invagination and infection. Nature Cell Biology 12, 11-18 (2010). https://doi.org/10.1038/ncb1999