Prof. Dr. Helge Ewers

Prof. Dr. Helge Ewers

Freie Universität Berlin
Institut für Chemie und Biochemie
Thielallee 63
14195 Berlin
Phone: +49 (30) 838 60644

Position and Status

Professor of Membrane Biochemistry (W3)

Scholarships and awards

2011 - Holcim Foundation Fellowship
2011 - Pfizer Research Prize
2008 - Hans-Heinrich-Niemann Prize for Dissertation
2007 - FEBS Long-Term Fellowship, SNF Fellowship (declined)

University training and degree

06/2002 - 03/2003 - Diploma thesis with Bettina Winckler at Mount Sinaii School of Medicine, New York, NY, USA
10/1997 - 06/2002 - Study of Biochemistry at Universität Hannover


Advanced academic qualifications

04/2007 - Dr. sc. in Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland, Mentor: Ari Helenius


Postgraduate Professional career

11/2014 – present - Professor of Membrane Biochemistry at Institute for Chemistry and Biochemistry, Freie Universität Berlin
06/2017 – present - Leader of Common Research Group for Soft X-Ray Microscopy, HZB
10/2013 – 10/2014 - Senior Lecturer in Cell Biology at the Randall Division of Cell and Molecular Biophysics, King’s College London, United Kingdom
06/2009 - 09/2013 - Group leader at ETH Zürich, Switzerland
09/2007 - 05/2009 - Post-doctoral research fellow with Daniel Choquet at CNRS UMR 5091, Bordeaux, France

Coordinating functions and editorial work

2017 - present - Repeated organizer of EMBO Workshop on Septins
2016 - present - Editor for Cell Biology at “Scientific Reports”
2010 - present - Founder and repeated organizer of SMLMS annual meeting series

Most important publications

  1. Dimou, E., Cosentino, K., Platonova, E., Ros, U., Sadeghi, M., Kashyap, P., Katsinelos, T., Wegehingel, S., Noé, F., Garcia-Saez, A., Ewers, H.* and Nickel, W.* (2019) Single event visualization of unconventional secretion of FGF2. J Cell Biol. 218, 683-699

  2. Gao, M., Maraspini, R., Beutel, O., Zehtabian, A., Eickholt, B., Honigmann, A.* and Ewers, H.* (2018) Expansion stimulated emission depletion Microscopy (ExSTED) ACS Nano 12, 4178- 4185

  3. Albrecht, D., Winterflood, C. M., Sadeghi, M., Tschager, T., Noé, F., and Ewers, H. (2016) Nanoscopic compartmentalization of membrane protein motion at the axon initial segment. J Cell Biol. 215, 37–46

  4. Mikhaylova M., Cloin, B.M.C., Finan, K., van den Berg, R., Teeuw, J., Kijanka, M.M., Sokolowski, M., Katrukha, E.A., Maidorn, M. Opazo, F., Moutel, S., Vantard, M. Perez, F.,van Bergen en Henegouwen, P.M.P., Hoogenraad, C.C., Ewers, H.*, and Kapitein, L.C.* (2015) Resolving bundled microtubules using anti-tubulin nanobodies. Nat Comm 6, 7933

  5. Kaplan, C., Jing, B., Winterflood, C.W., Bridges, A.A., Occhipinti, P., Schmied, J., Grinhagens, S., Gronemeyer, T., Tinnefeld, P., Gladfelter, A.S., Ries, J. and Ewers, H. (2015) The absolute arrangement of subunits in cytoskeletal septin filaments in cells measured by fluorescence microscopy. Nano Lett. 15(6):3859-64.

  6. Ries, J., Kaplan, C., Platonova, E., Eghlidi, H. and Ewers, H. (2012) A simple, versatile method for GFP-based single molecule localization microscopy via nanobodies. Nat. Methods. 9, 582–584

  7. Szklarczyk, O., Gonzales-Segredo, N., Kukura, P., Oppenheim, A., Choquet, D., Sandoghdar, V., Helenius, A., Sbalzarini, I.F. and Ewers, H. Receptor concentration and diffusivity control multivalent binding of SV40 to membrane bilayers. (2013) PLoS Comp Biol 9(11) e1003310

  8. Winterflood, C.M., Platonova, E., Albrecht, D. and Ewers H. (2015) Simple and robust dual color 3D superresolution microscopy by combined spectral-demixing and bi-plane imaging. Biophys J 109 (1) 3-6

  9. Favuzzi, E., Marques-Smith, A., Deogracias, R., Winterflood, C.M., Sanchez-Aguilera, A., Mantoan, L., Maeso, P., Fernandes, C., Ewers, H. and Rico, B. (2017) Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron 95, 1-17

  10. Ewers, H.*, Roemer, W.*, Smith, A.E., Bacia, K., Dmitrieff, S., Chai, W., Mancini, R., Kartenbeck, J., Chambon, V., Berland, L., Oppenheim, A., Schwarzmann, G., Feizi, T., Schwille, P., Sens, P., Helenius, A. & Johannes, L. (2010) SV40 binding to its receptor, GM1, induces membrane invagination, tubulation and infection. Nat. Cell Biol. 12(1) 11-8.