Dr. Alessia Ruggieri

Dr. Alessia Ruggieri

Medizinische Fakultät Heidelberg
der Universität Heidelberg
Zentrum für Infektiologie
Molekulare Virologie
Im Neuenheimer Feld 345
69120 Heidelberg
Phone: +49 (6221) 56-7761
Fax: +49 (6221) 56-4570
E-mail: alessia.ruggieri@med.uni-heidelberg.de

Research Area

Molecular Biology, Molecular Virology, Cell Biology

Position and Status

Group Leader

Scholarships and awards

2014 - 2016    Fellowship of Chica and Heinz Schaller Foundation

Academic Education

09/1999 - 11/2003   PhD thesis with Francois-Loic Cosset at the Ecole Normale Supérieure de Lyon, France
09/1998 - 09/1999   Diploma thesis with Francois-Loic Cosset at the Ecole Normale Supérieure de Lyon, France
09/1996 - 09/1998   Master thesis at University of Lyon, France
09/1994 - 09/1996   Study of Biology at the University of Metz, France


University Degrees

2003   PhD in Virology, Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Ecole Normale Supérieure de Lyon, France; Mentor: Francois-Loic Cosset



11/2013 -                 Group Leader at the Department of Infectious Diseases, Molecular Virology, University of Heidelberg
07/2008 - 11/2013   Postdoctoral research fellow with Ralf Bartenschlager at the Department of Infectious Diseases, Molecular Virology, University of Heidelberg
03/2004 - 07/2008   Postdoctoral research fellow with Jens Mayer at the Institute for Human genetics, University of Saarland

  1. Schmid B*, Rinas M*, Ruggieri A, Reuter A, Fischl W, Harder N, Bergeest J-P, Flossdorf M, Rohr K, Höfer T, Bartenschlager R. (2015) Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant. PloS Pathog. 11(12):e1005345. doi: 10.1371/journal.ppat.1005345.
  2. Trotart M, Tsopoulidis N, Tibroni N, Willemsen J, Binder M, Ruggieri A, Fackler OT (2015) Sensing of HIV-1 infection in Tzm-bl cells with reconstituted expression of STING. J Virol. pii: JVI.02966-15. [Epub ahead of print].
  3. Hiet M-S, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A† , Bartenschlager R† (2015) Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. J Hepatol. 63:829-37. † Co-corresponding authors
  4. Grünvogel O, Esser-Nobis K, Reustle A, Schult P, Müller B, Metz P, Trippler M, Windisch MP, Frese M, Binder M, Fackler O, Bartenschlager R, Ruggieri A, Lohmann V (2015) Dead box helicase 60-like (DDX60L) is an interferon stimulated gene restricting hepatitis C virus replication in cell culture. J Virol. 89:10548-68
  5. Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G and Bartenschlager R (2012) Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 12:71-85
  6. Bauhofer O, Ruggieri A, Schmid B, Schirmacher P, Bartenschlager R (2012) Persistance of HCV in quiescent hepatic cells during an interferon-induced antiviral response. Gastroenterology 143:429-438
  7. Metz P, Dazert E, Ruggieri A, Mazur J, Kaderali L, Kaul A, Zeuge U, Trippler M, Lohmann V, Binder M, Frese M, Bartenschlager R (2012) Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology 56:2082-2093
  8. Ruggieri A, Maldener E, Sauter M, Mueller-Lantzsch N, Meese E, Fackler OT, Mayer J (2009) Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec. Retrovirology 16:6-17
  9. Flockerzi A, Ruggieri A, Frank O, Medstrand P, Kopper B, Wullich B, Seifarth W, Leib-Mösch C, Meese E, Mayer J (2008) Expression pattern of transcribed human endogenous HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project. BMC Genomics 9:354
  10. Ruggieri A*, Cheynet V*, Oriol G, Blond JL, Boson B, Vachot L, Verrier B, Cosset FL, Mallet F (2005) Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope. J Virol. 79(9):5585-93 *Equal contributions