Dr. Alessia Ruggieri

Dr. Alessia Ruggieri

Medizinische Fakultät der Universität Heidelberg
Zentrum für Infektiologie, Molekulare Virologie
Im Neuenheimer Feld 344
69120 Heidelberg
Phone: +49 (6221) 56-7761
E-mail: alessia.ruggieri@med.uni-heidelberg.de


Research Area

Infectious diseases and molecular virology


Position and Status

Independent Research Group Leader

Department of Infectious Diseases, Molecular Virology Center for Integrative Infectious Disease Research (CIID) Heidelberg University, Germany.


Scholarships and awards

2014 - 2016 - Fellowship of Chica and Heinz Schaller Foundation



University training and degree

09/1998 - 09/1999 - Diploma thesis with Francois-Loic Cosset at the Ecole Normale Supérieure de Lyon, France
09/1996 - 09/1998 - Master thesis at University of Lyon, France
09/1994 - 09/1996 - Study of Biology at the University of Metz, France

 

Advanced academic qualifications

11/2003 - PhD in Virology, Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Ecole Normale Supérieure de Lyon, France with Francois-Loic Cosset

 

Postgraduate professional career

11/2013 - present - Group Leader at the Department of Infectious Diseases, Molecular Virology, University of Heidelberg
07/2008 - 11/2013 - Postdoctoral research fellow with Ralf Bartenschlager at the Department of Infectious Diseases, Molecular Virology, University of Heidelberg
03/2004 - 07/2008 - Postdoctoral research fellow with Jens Mayer at the Institute for Human genetics, University of Saarland

2023 Organizer of International Symposium "Membranes and Modules”, Berlin, Germany

2022 Organizer of “MINDS and RMaP Campus Day on RNA modifications”, Heidelberg, Germany

2017 Organizer of the “2nd International Symposium on Stress-Associated RNA Granules in Human Disease and Viral Infection.” Heidelberg, Germany

Most important publications

  1. Prasad, V., Cerikan, B., Stahl, Y., Kopp, K., Magg, V., Acosta-Rivero, N., Kim, H., Klein, K., Funaya, C., Haselmann, U., Cortese, M., Heigwer, F., Bageritz, J., Bitto, D., Jargalsaikhan, S., Neufeldt, C., Pahmeier, F., Boutros, M., Yamauchi, Y., Ruggieri, A. & Bartenschlager, R. Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2. Molecular Cell 83, 2559-2577.e2558 (2023). https://doi.org/10.1016/j.molcel.2023.06.020
  2. Klein, P., Kallenberger, S. M., Roth, H., Roth, K., Ly-Hartig, T. B. N., Magg, V., Aleš, J., Talemi, S. R., Qiang, Y., Wolf, S., Oleksiuk, O., Kurilov, R., Di Ventura, B., Bartenschlager, R., Eils, R., Rohr, K., Hamprecht, F. A., Höfer, T., Fackler, O. T., Stoecklin, G. & Ruggieri, A. Temporal control of the integrated stress response by a stochastic molecular switch. Science Advances 8, eabk2022 https://doi.org/10.1126/sciadv.abk2022
  3. Talemi, S. R., Bartenschlager, M., Schmid, B., Ruggieri, A., Bartenschlager, R. & Höfer, T. Dengue virus is sensitive to inhibition prior to productive replication. Cell Reports 37 (2021). https://doi.org/10.1016/j.celrep.2021.109801
  4. Haneke, K., Schott, J., Lindner, D., Hollensen, A. K., Damgaard, C. K., Mongis, C., Knop, M., Palm, W., Ruggieri, A. & Stoecklin, G. CDK1 couples proliferation with protein synthesis. Journal of Cell Biology 219, e201906147 (2020). https://doi.org/10.1083/jcb.201906147
  5. Brocard, M., Iadevaia, V., Klein, P., Hall, B., Lewis, G., Lu, J., Burke, J., Willcocks, M. M., Parker, R., Goodfellow, I. G., Ruggieri, A. & Locker, N. Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation. PLOS Pathogens 16, e1008250 (2020). https://doi.org/10.1371/journal.ppat.1008250
  6. Roth, H., Magg, V., Uch, F., Mutz, P., Klein, P., Haneke, K., Lohmann, V., Bartenschlager, R., Fackler Oliver, T., Locker, N., Stoecklin, G. & Ruggieri, A. Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses. mBio 8, 10.1128/mbio.02150-02116 (2017). https://doi.org/10.1128/mbio.02150-16
  7. Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R. Ultrastructural characterization of Zika virus replication factories. Cell Rep. 18, 2113–2123 (2017) https://doi.org/10.1016/j.celrep.2017.02.014
  8. Chatel-Chaix, L., Cortese, M., Romero-Brey, I., Bender, S., Neufeldt, C. J., Fischl, W., Scaturro, P., Schieber, N., Schwab, Y., Fischer, B., Ruggieri, A. & Bartenschlager, R. Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell Host & Microbe 20, 342-356 (2016). https://doi.org/10.1016/j.chom.2016.07.008
  9. Hiet, M.-S., Bauhofer, O., Zayas, M., Roth, H., Tanaka, Y., Schirmacher, P., Willemsen, J., Grünvogel, O., Bender, S., Binder, M., Lohmann, V., Lotteau, V., Ruggieri, A. & Bartenschlager, R. Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. Journal of Hepatology 63, 829-837 (2015). https://doi.org/10.1016/j.jhep.2015.04.015
  10. Ruggieri, A., Dazert, E., Metz, P., Hofmann, S., Bergeest, J.-P., Mazur, J., Bankhead, P., Hiet, M.-S., Kallis, S., Alvisi, G., Samuel, Charles E., Lohmann, V., Kaderali, L., Rohr, K., Frese, M., Stoecklin, G. & Bartenschlager, R. Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection. Cell Host & Microbe 12, 71-85 (2012). https://doi.org/10.1016/j.chom.2012.05.013