Prof. Dr. Florian Heyd

Prof. Dr. Florian Heyd

Freie Universität Berlin
Institut für Chemie und Biochemie
Takustr. 6
14195 Berlin
Phone: +49 (30) 838 62938
Fax: +49 (30) 838 56919

Research Area

RNA Biochemistry, alternative splicing, T cell biology, circadian clock

Position and Status

Professor of RNA Biochemistry (W2)

Scholarships and awards

2015               ‘Prize for good teaching’ awarded by the association of biochemistry students
2008 - 2011    DFG Research fellowship
2006               Promotion ‘summa cum laude’
2004 - 2005    Scholarship of the ‘Studienstiftung des deutschen Volkes’ (Doktorandenförderung)
2000 - 2002    Scholarship of the ‘Studienstiftung des deutschen Volkes’ (Grundförderung)

Academic Education

01/2003 - 04/2006   Graduate student, University of Essen, T. Möröy
10/1997 - 05/2002   Biochemistry (Diplom), FU Berlin and University of Cambridge (England), Diploma thesis supervised by J.K. Sethi (Cambridge)


University Degrees

04/2006   Dr. rer. nat. (Cell biology), University of Essen, 2006, supervised by T. Möröy



10/2013 -                 Professor of RNA Biochemistry (W2), FU Berlin
04/2011 - 09/2013   Leader of the independent Emmy-Noether-Group ‘Functional consequences of alternative splicing in T cells’, Philipps University Marburg
04/2008 - 03/2011   Postdoctoral fellow, UTSW, Dallas and UPenn, Philadelphia, K. Lynch
05/2006 - 03/2008   Postdoctoral fellow, IRCM, Montreal, T. Möröy


  1. Preußner M, Wilhelmi I, Schultz AS, Finkernagel F, Michel M, Möröy T, Heyd F. (2014) Rhythmic U2af26 Alternative Splicing Controls PERIOD1 Stability and the Circadian Clock in Mice. Mol Cell. 54: 651-62.
  2. Michel M, Wilhelmi I, Schultz AS, Preussner M, Heyd F. (2014) Activation-induced Tumor Necrosis Factor Receptor-associated Factor 3 (Traf3) Alternative Splicing Controls the Noncanonical Nuclear Factor κB Pathway and Chemokine Expression in Human T Cells. J Biol Chem. 289: 13651-60.
  3. Gaudreau MC, Heyd F, Bastien R, Wilhelm B, Möröy T. (2012) Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells. J Immunol. 188: 5377-88.
  4. Martinez NM, Pan Q, Cole BS, Yarosh CA, Babcock GA, Heyd F, Zhu W, Ajith S, Blencowe BJ, Lynch KW. (2012) Alternative splicing networks regulated by signaling in human T cells. RNA. 18: 1029-40.
  5. Heyd F, Lynch KW. 2011. PSF controls expression of histone variants and cellular viability in thymocytes. Biochem Biophys Res Commun. 414: 743-9.
  6. Heyd F, Chen R, Afshar K, Saba I, Lazure C, Fiolka K, Möröy T. (2011) The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1. Biochim Biophys Acta. 1809: 255-61.
  7. Heyd F, Lynch KW. (2010) Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. Mol Cell. 40: 126-37.
  8. Motta-Mena LB, Heyd F, Lynch KW. (2010) Context-dependent regulatory mechanism of the splicing factor hnRNP L. Mol Cell. 37: 223-34.
  9. Heyd F, Carmo-Fonseca M, Möröy T. (2008) Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26. J Biol Chem. 283: 19636-45.
  10. Heyd F, ten Dam G, Möröy T. (2006) Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing. Nat Immunol. 7: 859-67