Prof. Dr. Ursula Klingmüller

Ursula Klingmüller

Deutsches Krebsforschungszentrum (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg
Phone: +49 (6221) 42-4481

Position and Status

Head of Division Systems Biology of Signal Transduction (B200), DKFZ / Professor (W3) Ruprecht-Karls-Universität Heidelberg

Scholarships and awards

Since 2016 - Election as Member of the German Ethics Council
2013 - 2014 - President of "Hinterzartener Kreis der DFG für Krebsforschung"
2012 - Elected Member of the DFG "Hinterzartener Kreis"
2004 - R. Eils, U. Klingmüller, O. Wiestler, E. Wanker,. A.-P. Zeng, R. Balling. ‘Systems Biology of Complex Diseases’ Ideenwettbewerb Helmholtz Association
1997 - FEBS Anniversary Prize
1986 - DAAD-Fellowship for a lab course at the University College, London
1993 - 1994 - DFG-Research Fellowship

University training and degree

1988 - Diploma in molecular biology, cell biology and virology, University of Heidelberg; Diploma thesis, Group of Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg (ZMBH) (with distinction, October 1988)
1985 - Bachelor of Science, University of Bayreuth (with distinction, November 1985)


Advanced academic qualifications

2004 - Venia Legendi in Cell Biology, Heidelberg University, Germany
2000 - Habilitation and Venia Legendi in Molecular Biology and Genetics, University of Freiburg
1992 - Graduate studies at Heidelberg University, Doctoral Thesis, Group of Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg, Germany (ZMBH), (summa cum laude, May 1992)


Postgraduate professional career

Since 2011 - W3 Professor, Heidelberg University, Germany
Since 2007 - Head of the division ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
2003 - 2007 - Group leader of the Boveri-group ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
1996 - 2003 - Group leader of an independent junior group,(Hans-Spemann-Laboratories) Max-Planck-Institute for Immunbiology, Freiburg, Germany
1992 - 1996 - Postdoctoral fellow, Harvard Medical School (Group of Prof. Dr. Lewis
C. Cantley) and Whitehead Institute for Biomedical Research (Group of Prof. Dr. Harvey F. Lodish)

Coordinating functions and editorial work

Since 2015 - Associate Editor for Nature Systems Biology and Applications
Since 2014 - Chair of the Executive Women's Initiative at DKFZ
Since 2010 - Member in selection committees of the DKFZ
Since 2007 - Coordination (together with Prof. Ursula Kummer) of Major Systems Biology in the Master Program Molecular Biosciences at Heidelberg University
2007 - 2015 - Board of Trustees German Cancer Research Center (DKFZ)

Most important publications

  1. Lucarelli, P., Schilling, M., Kreutz, C., Vlasov, A., Boehm, M.E., Iwamoto, N., Steiert, B., Lattermann, S., Wäsch, M., Stepath, M., Matter, M.S., Heikenwälder, M., Hoffmann, K., Deharde, D., Damm, G., Seehofer, D., Muciek, M., Gretz, N., Lehmann, W.D., Timmer, J., Klingmüller, U. (2018) Resolving the combinatorial complexity of smad protein complex formation and its link to gene expression. Cell Systems. 6(1):75-89.e11

  2. Adlung, L., Kar, S., Wagner, M.C., She, B., Chakraborty, S., Bao, J., Lattermann, S., Boerries, M., Busch, H., Timmer, J., Schilling, M., Höfer, T., Klingmüller, U. (2017) Protein abundance of AKT and ERK pathway components governs cell-type-specific regulation of proliferation. Molecular Systems Biology. 13(1):904

  3. Marwitz, S., Depner, S., Dvornikov, D., Merkle, R., Szczygiel, M., Müller-Decker, K., Lucarelli, P., Wäsch, M., Mairbäurl, H., Rabe, K.F., Kugler, C., Vollmer, E., Reck, M., Scheufele, S., Kröger, M., Ammerpohl, O., Siebert, R., Goldmann, T., Klingmüller, U. (2016) Downregulation of the TGF-ß pseudoreceptor BAMBI in non-small cell lung cancer enhances TGF-ß signaling and invasion. Cancer Research. 76(13):3785-3801

  4. Iwamoto, N., D’Alessandro, L.A., Depner, S., Hahn, B., Kramer, B.A., Lucarelli, P., Vlasov, A., Stepath, M., Böhm, M.E., Deharde, D., Damm, G., Seehofer, D., Lehmann, W.D., Klingmüller, U., Schilling, M. (2016) Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation. Science Signaling. 9(413):ra13

  5. Mueller, S., Huard, J., Waldow, K., Huang, X., D’Alessandro, L.A., Bohl, S., Börner, K., Grimm, D., Klamt, S., Klingmüller, U., Schilling, M. (2015) T160-phosphorylated CDK2 defines threshold for HGF- dependent proliferation in primary hepatocytes. Molecular Systems Biology. 11(3):795

  6. Bachmann, J., Raue, A., Schilling, M., Boehm, ME., Kreutz, C., Kaschek, D., Busch, H., Gretz, N., Lehmann, WD., Timmer, J., Klingmüller, U. (2011) Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Molecular Systems Biology. 7:516

  7. Becker, V., Schilling, M., Bachmann, J., Baumann, U., Raue, A., Maiwald, T., Timmer, J., Klingmüller, U. 2010. Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor. Science. 328(5984):1404-8

  8. Swameye, I., Müller, T. G., Timmer, J., Sandra, O., and Klingmüller, U. (2003) Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-based dynamic modeling. Proc. Natl. Acad. Sci. USA. 100:1028-33

  9. Klingmüller ,U., Bergelson, S., Hsiao, J.G., and Lodish, H.F. (1996) Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. Proc. Natl. Acad. Sci. USA. 93:8324-8328

  10. Klingmüller, U., Lorenz, U., Cantley, L.C., Neel, B.G., and Lodish, H.F. (1995) Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 80:729-738


  1. Klingmüller, U., and Michnick, S., (1995), Assays for agents which alter erythropoietin activity. Pending US patent application 08/914,706.
  2. Swameye, I., Müller, T., Timmer, J., and Klingmüller, U., (2001), Methods,System and Use of the Method and the System for Identifying Targets for Efficient Medical Intervention and /or for Predicting the Effect of Therapeutic Agents and/or for Dynamically Modeling Complex Cell Signaling Networks. Patent pending. Pending US patent application 10/475,930.

  3. Schilling, M., Maiwald, T., Bohl, S., Kreutz, C., Timmer, J., and Klingmüller, U., (2005), Method for processing and error reduction for standardized quantitative data in biological networks, PCT/EP2006/069274.

  4. Schilling M., Rodriguez-Gonzalez, A., Timmer, J., Raue, A., Schelker, M., Klingmüller, U., Jarsch, M. (2014) Methods for the Prediction of a Perzonalized ESA-Dose in the Treatment of Anemia. EP14173054.9

  5. Rodriguez-Gonzalez, A., Schilling, M., Klingmüller, U., Timmer, J., and Steiert, B. (2017) Prediction- method of mortality due to treatment with erythropoiesis stimulating agents. EP17153796.2