Prof. Dr. Christian Rosenmund
Charite - Universitätsmedizin Berlin
Department of Neurophysiology, NeuroCure
Charitéplatz 1
10117 Berlin
Phone: +49 (0)30 450 539-061,
E-mail: christian.rosenmund@charite.de
Research Area
Neurobiology
Position and Status
Professor of Neurobiology (W3)
Scholarships and awards
2019 - present Member of the German National Academy of Sciences Leopoldina
2018 - Director, FENS Course: Introduction to synaptic transmission at the central synapse, Berlin, Germany
2018 - Instructor, Advanced Imaging Methods, Bordeaux, France
Since 2015 - Scientific Advisory Board, Department Biomedicine, University Basel, CH
Since 2014 - Board of Trustees of the Schram Foundation, Essen, Germany
2014 - 2018 - Berlin Institute of Health, Coordinator of Collaborative Research Grant ‘Congenital Diseases’, Berlin, Germany
2012 - 2018 - Reviewing Editor, eLIFE
2012 - 2015 - Speaker of Cluster of Excellence NeuroCure, Berlin, Germany
2010 - 2018 - Speaker and Coordinator of Collaborative Research Center 665 Developmental Disturbances in the Nervous System’, Berlin, Germany
2010 - 2015 - European Research Council Advanced Grant
2007 - 2010 - HFSP (Human Frontier Science Program) award # RGP35/2007
2007 - 2009 - International Rett Syndrome Foundation Research grant
2005 - 2010 - NIH HD024064 Synaptic Physiology core facility grant
2005 - 2010 - NIH R01 Research grant NS050655
2005 - 2010 - NIH R01 Research grant NS051262
1999 - 2003 - Heisenberg Stipend
1995 - 1997 - Helmholtz Stipend
1993 - 1995 - Howard Hughes Research Fellowship
1991 - 1992 - Tartar Trust Fellowship
University training and degree
09/1984 - 06/1989 - 3rd Staatsexamen in Pharmacy, Goethe University Frankfurt, Germany, state- licensed pharmacist
Advanced academic qualifications
1999 - Habilitation, Physiology, Georg-August-Universität Göttingen, Prof. Diethelm Richter
02/1993 - PhD in Neuroscience and Physiology, Vollum Institute, Oregon Health Sciences University, Portland, OR USA, Prof. Gary Westbrook
Postgraduate professional career
07/2009 - present - Professor of Neurobiology (W3) at the Charité as part of the NeuroCure Cluster of Excellence, Institute for Neurophysiology, Charité, Berlin
02/2008 - 06/2010 - Full Professor, Department of Molecular and Human Genetics and Department of Neuroscience (joint primary appointment), Baylor College of Medicine (BCM), Houston, TX USA
02/2005 - 06/2010 - Director, Mouse Synaptic Plasticity Core, Mental Retardation Research Center, Baylor College of Medicine (BCM)
12/2003 - 01/2008 - Associate Professor, Department of Molecular and Human Genetics and Department of Neuroscience (joint primary appointment), BCM
1999 - 2003 - Group leader at Max Planck Institute for Biophysical Chemistry
01/1998 - 01/2003 - Principal Investigator and Heisenberg Fellow (2/1999), Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry (MPI Göttingen), Göttingen, Germany (Institute Head: Prof. Erwin Neher)
07/1995 - 06/1997 - Helmholtz Fellow + senior postdoc, Workgroup Cellular Neurobiology (Advisor: Prof. Alain Marty), MPI Göttingen
07/1993 - 06/1995 - Howard Hughes Fellow, Molecular Neurobiology Laboratories, The Salk Institute, La Jolla, CA USA (Advisor: Prof. Charles Stevens)
02/1993 - 06/1993 - Postdoctoral Fellow, Vollum Institute, Oregon Health Sciences University, Portland, OR, USA (Advisor: Prof. Gary Westbrook)
2019 – present Charité Center for Basic Sciences, Deputy-Director, Institute for Neurophysiology
2009 – present Member, Board of Directors, NeuroCure Cluster of Excellence
2014 – 2018 Coordinator, Berlin Institute of Health, Collaborative Research Grant“congenital diseases”
2009 – 2017 Director of the DFG Collaborative Research Center ‘Developmental Disturbances in the Nervous System’
2012 – 2015 Director of 25 PI German Research Council (DFG) consortium NeuroCure - Cluster of Excellence, Berlin
2008 – 2010 Full Professor, Department of Molecular and Human Genetics and Department of Neuroscience (joint primary appointment), Baylor College of Medicine (BCM), Houston, TX USA
2005 – 2010 Faculty, Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX
2005 – 2008 Director, Mouse Synaptic Plasticity Core, Mental Retardation Research Center at Baylor College of Medicine, Houston, TX
2003 – 2008 Associate Professor, Department of Molecular and Human Genetics and Department of Neuroscience (joint primary appointment), Baylor College of Medicine (BCM), Houston, TX, USA
Editorial work
2014 - Berlin Institute of Health, Coordinator of Collaborative Research Grant ‘Congenital Diseases’
2013 - Reviewing Editor, eLIFE
2012 - Speaker of Cluster of Excellence NeuroCure
2010 - Speaker of Collaborative Research Center 665 ‘Developmental Disturbances in the Nervous System’
Most important publications
- Watanabe, S., Trimbuch, T., Camacho-Pérez, M., Rost, B. R., Brokowski, B., Söhl-Kielczynski, B., Felies, A., Davis, M. W., Rosenmund, C. & Jorgensen, E. M. Clathrin regenerates synaptic vesicles from endosomes. Nature 515, 228-233 (2014). https://doi.org/10.1038/nature13846
- Grauel, M. K., Maglione, M., Reddy-Alla, S., Willmes, C. G., Brockmann, M. M., Trimbuch, T., Rosenmund, T., Pangalos, M., Vardar, G., Stumpf, A., Walter, A. M., Rost, B. R., Eickholt, B. J., Haucke, V., Schmitz, D., Sigrist, S. J. & Rosenmund, C. RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proceedings of the National Academy of Sciences 113, 11615-11620 (2016). https://doi.org/10.1073/pnas.1605256113
- Rost, B. R., Schneider, F., Grauel, M. K., Wozny, C., G Bentz, C., Blessing, A., Rosenmund, T., Jentsch, T. J., Schmitz, D., Hegemann, P. & Rosenmund, C. Optogenetic acidification of synaptic vesicles and lysosomes. Nature Neuroscience 18, 1845-1852 (2015). https://doi.org/10.1038/nn.4161
- Vardar, G., Chang, S., Arancillo, M., Wu, Y.-J., Trimbuch, T. & Rosenmund, C. Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons. The Journal of Neuroscience 36, 7911 (2016). https://doi.org/10.1523/JNEUROSCI.1314-16.2016
- Camacho, M., Basu, J., Trimbuch, T., Chang, S., Pulido-Lozano, C., Chang, S.-S., Duluvova, I., Abo-Rady, M., Rizo, J. & Rosenmund, C. Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming. Nature Communications 8, 15293 (2017). https://doi.org/10.1038/ncomms15293
- Chang, S., Trimbuch, T. & Rosenmund, C. Synaptotagmin-1 drives synchronous Ca2+- triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment. Nature Neuroscience 21, 33-40 (2018). DOI: 10.1038/s41593-017-0037-5
- Quade, B., Camacho, M., Zhao, X., Orlando, M., Trimbuch, T., Xu, J., Li, W., Nicastro, D., Rosenmund, C. & Rizo, J. Membrane bridging by Munc13-1 is crucial for neurotransmitter release. eLife 8, e42806 (2019). https://doi.org/10.7554/eLife.42806
- Zarebidaki, F., Camacho, M., Brockmann, M. M., Trimbuch, T., Herman, M. A. & Rosenmund, C. Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission. The Journal of Neuroscience 40, 9372 (2020). https://doi.org/10.1523/JNEUROSCI.1922-20.2020
- Camacho, M., Quade, B., Trimbuch, T., Xu, J., Sari, L., Rizo, J. & Rosenmund, C. Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region. eLife 10, e72030 (2021).https://doi.org/10.7554/eLife.72030
- Bouazza-Arostegui, B., Camacho, M., Brockmann, M. M., Zobel, S. & Rosenmund, C. Deconstructing Synaptotagmin-1’s Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release. The Journal of Neuroscience 42, 2856 (2022). https://doi.org/10.1523/JNEUROSCI.1945-21.2022
*corresponding authors.