Prof. Dr. Achim Kramer

Prof. Dr. Achim Kramer

Charité - Universitätsmedizin Berlin
Institut für medizinische Immunologie
Hessische Str. 3-4
10115 Berlin
Phone: +49 (30) 450-524263
Fax: +49 (30) 450-524942
E-mail: achim.kramer@charite.de


Research Area

Chronobiology, Molecular Cell Biology, Biochemistry


Position and Status

Professor of Chronobiology (W2)


Scholarships and awards

2010, 2011, 2013, 2015    Teaching Awards of the Charité Master-Program „Medical Neurosciences“
2007                                  Call to a Full Professorship (W3) in Molecular Biology at the University Duisburg-Essen (declined)
2002                                  Heinz-Maier-Leibnitz Award from the German Research Foundation (DFG)
2001                                  Brooks Fellow at Harvard Medical School
1999 - 2001                       Postdoctoral fellowship from the German Research Foundation (DFG)
1998                                  Young Researcher’s Award, Charité - Universitätsmedizin Berlin
1994 - 1996                       Graduation Fellowship of the "Fonds der Chemischen Industrie"



Academic Education

1993 - 1996   Ph.D. thesis with Jens Schneider-Mergener at the Institute of Medical Immunology, Charité Universitätsmedizin Berlin
1993              Diploma thesis with Jens Schneider-Mergener at Charité-Universitätsmedizin Berlin
1990 - 1994   Study of Music (piano) at Hochschule der Künste, Berlin
1988 - 1993   Study of Biochemistry at Freie Universität, Berlin

 

University degrees

1996   Ph.D. in Biochemistry, Humboldt Universität zu Berlin; Mentor: Jens Schneider-Mergener (summa cum laude)
1994   Degree as Piano Teacher, Hochschule der Künste, Berlin

 

Employment

2011 -            Chair of the independent Research Unit “Chronobiology” at Charité Universitätsmedizin Berlin
2007 -            Professor for Chronobiology at Charité-Universitätsmedizin Berlin (W2, tenured)
2002 - 2007   Assistant Professor (Juniorprofessor) for Chronobiology at Charité - Universitätsmedizin Berlin
2002 - 2007   Junior Research Emmy-Noether Group Leader (German Research Fondation, DFG) at Charité Universitätsmedizin Berlin
1999 - 2001   Postdoc at the Department of Neurobiology, Harvard Medical School, Boston, USA (Charles Weitz)
1998              Postdoc at the Istituto Di Ricerche Di Biologia Moleculare (IRBM) in Rom, Italy (Riccardo Cortese)
1996 - 1999   Postdoc at the Institute of Medical Immunology, Charité-Universitätsmedizin Berlin

2015     Chair of Gordon Research Conference “Chronobiology”
2014 -   Member of “Executive Committee” der “Society for Research on Biological Rhythms”
2013 -   Associate Editor of PLoS Genetics
2013 -   Editorial Board Member of Journal of Biological Rhythms
2013     Editor of “Circadian Clocks”, Handbook of Experimental Pharmacology (Springer)
2013     Vice-Chair of Gordon Research Conference “Chronobiology”
2012 -   Member of “Executive Board” of the „European Biological Rhythms Society“

  1. Öllinger, R., Korge, S., Korte, T., Koller, B., Hermann, A., and Kramer A. (2014) Dynamics of the circadian clock protein PERIOD2 in living cells. J Cell Sci. 127:4322-4328.
  2. Schmalen, I., Reischl, S., Wallach, T., Klemz, R., Grudziecki, A., Prabu, J.R., Benda, C., and Kramer, A.* & Wolf, E.* (2014) Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. Cell 157:1203-1215. (*=corresponding authors)
  3. Wallach T., Schellenberg K., Maier B., Kalathur R., Porras P., Wanker E.E., Futschik M., and Kramer A. (2013) Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. PloS Genetics 9:e1003398.
  4. Czarna, A., Berndt, A., Singh, H.R., Grudziecki, A., Ladurner, A.G., Timinszky, G., Kramer, A., Wolf, E. (2013) Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell 153:1394-405.
  5. Spörl, F., Korge, S., Jürchott, K., Wunderskirchner, M., Schellenberg, K., Heins, S., Specht, A., Stoll, C., Klemz, R., Maier, B., Wenck, H., Schrader, A., Kunz, D., Blatt, T., and Kramer, A. (2012) Krüppel- like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. Proc Natl Acad Sci USA. 109:10903-10908.
  6. Maier, B, Wendt, S, Vanselow, J.T., Wallach, T, Reischl, S., Oehmke, S., Schlosser, A., and Kramer, A. (2009) A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes Dev. 23:708-718.
  7. Keller, M., Mazuch, J., Abraham, U., Eom, G.D., Herzog, E.D., Volk, H.D., Kramer, A.*, and Maier, B. (2009) A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci USA. 106:21407-12. (*=corresponding author)
  8. Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, and Kramer A. (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev. 20:2660-72.
  9. Kramer, A., Yang, F.-C., Snodgrass, P., Li, X.-D., Scammel, T.E., Davis, F., and Weitz, C.J. (2001) Regulation of daily locomotor activity, sleep by hypothalamic EGF receptor signalling. Science 294:2511-2515.
  10. Kramer, A., Keitel, T., Höhne, W., and Schneider-Mergener, J. (1997) Molecular basis of the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody. Cell 91, 799-809.