Prof. Dr. Ana Martin-Villalba

Coordinating functions and editorial work

2019 - Evaluation of SFO stem cells and regenerative medicine, Karolinska Institutet, SE
2013, 2018 - Scientific Evaluation, Collaborative Research Center, SFB 870, LMU, Munich, DE
2013 - Member of the Jury, Falling Walls Lab, Berlin, DE
Since 2007 - Reviewer for: Nature, Science, Cell Stem Cell, Genes & Development, NCB,Dev Cell, Neuron, J Neurosci, J Exp Med, Cancer Research, Oncogene, EMBO, and other high IF journals

Grant Reviewing for the German research foundation (DFG) since 2008, French national research agency (ANR) 2011 and 2016; Wings for Life (since 2008), Margarete von Wrangell-Habilitationsprogramm für Frauen (2014); Deutsche Krebshilfe (2016); Humboldt foundation (2017), Research foundation flanders (FWO) 2017, SFB 870 Begutachtung (München) 2013 and 2017, On-site visit Einstein Center for Regenerative Therapies (Berlin) 2016 and 2018

Most important publications

1. Carvajal Ibañez, D., Skabkin, M., Hooli, J., Cerrizuela, S., Göpferich, M., Jolly, A., Volk, K., Zumwinkel, M., Bertolini, M., Figlia, G., Höfer, T., Kramer, G., Anders, S., Teleman, A. A., Marciniak-Czochra, A. & Martin-Villalba, A. Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle. EMBO Molecular Medicine 15, e16434 (2023). https://doi.org/10.15252/emmm.202216434
2. Gülcüler Balta, G. S., Monzel, C., Kleber, S., Beaudouin, J., Balta, E., Kaindl, T., Chen, S., Gao, L., Thiemann, M., Wirtz, C. R., Samstag, Y., Tanaka, M. & Martin-Villalba, A. 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Cell Reports 29, 2295-2306.e2296 (2019). DOI: 10.1016/j.celrep.2019.10.054
3. Baser, A., Skabkin, M., Kleber, S., Dang, Y., Gülcüler Balta, G. S., Kalamakis, G., Göpferich, M., Ibañez, D. C., Schefzik, R., Lopez, A. S., Bobadilla, E. L., Schultz, C., Fischer, B. & Martin- Villalba, A. Onset of differentiation is post-transcriptionally controlled in adult neural stem cells. Nature 566, 100-104 (2019). https://doi.org/10.1038/s41586-019-0888-x
4. Kalamakis, G., Brüne, D., Ravichandran, S., Bolz, J., Fan, W., Ziebell, F., Stiehl, T., Catalá- Martinez, F., Kupke, J., Zhao, S., Llorens-Bobadilla, E., Bauer, K., Limpert, S., Berger, B., Christen, U., Schmezer, P., Mallm, J. P., Berninger, B., Anders, S., del Sol, A., Marciniak- Czochra, A. & Martin-Villalba, A. Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Cell 176, 1407-1419.e1414 (2019). DOI: 10.1016/j.cell.2019.01.040
5. Chen, S., Tisch, N., Kegel, M., Yerbes, R., Hermann, R., Hudalla, H., Zuliani, C., Gülcüler, G. S., Zwadlo, K., von Engelhardt, J., Ruiz de Almodóvar, C. & Martin-Villalba, A. CNS Macrophages Control Neurovascular Development via CD95L. Cell Reports 19, 1378-1393 (2017). https://doi.org/10.1016/j.celrep.2017.04.056
6. Drachsler, M., Kleber, S., Mateos, A., Volk, K., Mohr, N., Chen, S., Cirovic, B., Tüttenberg, J., Gieffers, C., Sykora, J., Wirtz, C. R., Mueller, W., Synowitz, M. & Martin-Villalba, A. CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells. Cell Death & Disease 7, e2209-e2209 (2016). https://doi.org/10.1038/cddis.2016.102
7. Wollny, D., Zhao, S., Everlien, I., Lun, X., Brunken, J., Brüne, D., Ziebell, F., Tabansky, I., Weichert, W., Marciniak-Czochra, A. & Martin-Villalba, A. Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas. Developmental Cell 39, 289-301 (2016). DOI: 10.1016/j.devcel.2016.10.002
8. Llorens-Bobadilla, E., Zhao, S., Baser, A., Saiz-Castro, G., Zwadlo, K. & Martin-Villalba, A. Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury. Cell Stem Cell 17, 329-340 (2015). https://doi.org/10.1016/j.stem.2015.07.002
9. Teodorczyk, M., Kleber, S., Wollny, D., Sefrin, J. P., Aykut, B., Mateos, A., Herhaus, P., Sancho-Martinez, I., Hill, O., Gieffers, C., Sykora, J., Weichert, W., Eisen, C., Trumpp, A., Sprick, M. R., Bergmann, F., Welsch, T. & Martin-Villalba, A. CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma. Cell Death & Differentiation 22, 1192- 1202 (2015). https://doi.org/10.1038/cdd.2014.217
10. Kleber, S., Sancho-Martinez, I., Wiestler, B., Beisel, A., Gieffers, C., Hill, O., Thiemann, M., Mueller, W., Sykora, J., Kuhn, A., Schreglmann, N., Letellier, E., Zuliani, C., Klussmann, S., Teodorczyk, M., Gröne, H.-J., Ganten, T. M., Sültmann, H., Tüttenberg, J., von Deimling, A., Regnier-Vigouroux, A., Herold-Mende, C. & Martin-Villalba, A. Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma. Cancer Cell 13, 235-248 (2008). https://doi.org/10.1016/j.ccr.2008.02.003

Patents

“Compounds inhibiting CD95 signaling for the treatment of pancreatic cancer”

PCT/EP2010/067491 granted 2009 in Europe.

“Combination of therapies to inhibit CD95L and TNF”
EP 1 235 592 granted November 14, 2007 in Europe (Deutschland, Schweiz)
AU 784102 granted May 18, 2006 in Australia http://v3.espacenet.com/publicationDetails/biblio?KC=A1&date=20020904&NR=1235592A1&DB=EPOD OC&locale=en_EP&CC=EP&FT=D

“Inhibition of the CD95 ligand/receptor system for the treatment of CNS trauma”
EP 1 592 446 granted May 7, 2008 in Europe (nationalisiert in: Frankreich, Belgien, Irland, Deutschland, Spanien, UK, Italien, Niederlande, Österreich, Schweden, Schweiz, Dänemark) http://v3.espacenet.com/publicationDetails/biblio?KC=A1&date=20051109&NR=1592446A1&DB=EPOD OC&locale=en_EP&CC=EP&FT=D ; exclusively licenced to Apogenix GmbH

“Neutralization of CD95 Activity Blocks Invasion of Glioblastoma Cells in Vivo”; PCT (WO2008080623);http://v3.espacenet.com/publicationDetails/biblio?KC=A2&date=20080710&NR=2008 080623A2&DB=EPODOC&locale=en_EP&CC=WO&FT=D

“The death receptor CD95 controls neurogenesis of adult neural stem cell in vivo and in vitro”; PCT (WO2008034608);http://v3.espacenet.com/publicationDetails/biblio?KC=A1&date=20080327&NR=2008 034608A1&DB=EPODOC&locale=en_EP&CC=WO&FT=D