Prof. Dr. Markus Wahl

Prof. Dr. Markus Wahl

Freie Universität Berlin
Institut für Chemie und Biochemie
Takustr. 6
14195 Berlin
Phone: +49 (0) 30 838-53456
Fax: +49 (0) 30 838-56981
E-mail: mwahl@zedat.fu-berlin.de


Research Area

Structural Biology, Biochemistry, Molecular Biology


Position and Status

Professor of Structural Biochemistry (W3)


Scholarships and awards

2014    Elected Member of the European Molecular Biology Organization (EMBO)
2011    Award for Excellent Teaching, Institute of Chemistry and Biochemistry, Freie Universität Berlin
1999    Postdoctoral Fellowship, Peter und Traudl Engelhorn-Stiftung
1999    Sidhu Award, Pittsburgh Diffraction Society
1997    Postdoctoral Fellowship, Deutsche Forschungsgemeinschaft
1996    Presidential Fellowship, The Ohio State University
1995    Chung Soo Yoo Award, Pittsburgh Diffraction Society
1995    Graduate Research Award, Department of Biochemistry, The Ohio State University
1993    Wilbur Wright Canaga Fellowship, The Ohio State University
1991    University Fellowship, The Ohio State University
1990    Fulbright Fellowship, Fulbright Association



Academic Education

1993 - 1996   PhD thesis with Muttaiya Sundaralingam, The Ohio State University
1992 - 1993   Master thesis with Alan G. Marshall, The Ohio State University
1991 - 1993   Study of Biochemistry, The Ohio State University
1990 - 1991   Fulbright Fellow in Biochemistry, University of Rochester
1987 - 1990   Study of Biochemistry, Leibniz Universität Hannover (Vordiplom 1989)

 

University Degrees

2002   Habilitation, venia legendi in Biochemistry Technische Universität München; Mentor: Robert Huber
1996   PhD in Biochemistry, The Ohio State University; Mentor: Muttaiya Sundaralingam

 

Employment

2013 -            Faculty Member, IRI Graduate School “Single Molecule RNA Biology“, Humboldt Universität zu Berlin
2011 -            Faculty Member, Leibniz Graduate School “Molecular Biophysics“, LeibnizInstitut für Molekulare Pharmakologie, Berlin-Buch
2009 -            Professor (W3) of Structural Biochemistry, Freie Universität Berlin
2008 - 2009   Professor (W2) of Macromolecular Crystallography, Georg-AugustUniversität Göttingen
2008 - 2009   Faculty Member, International Max-Planck Research School “Physics of Biological and Complex Systems“, Max-Planck-Institut für Biophysikalische Chemie and Georg-August-Universität Göttingen
2007 - 2009   Faculty Member, Graduate School “Biomolecules: Structure-FunctionDynamics”, Georg-August-Universität Göttingen
2006              Call as a Professor (W3) of Biochemistry, Universität Bayreuth; declined
2003 - 2009   Faculty Member, International Max-Planck Research School “Molecular Biology“, Max-Planck-Institut für Biophysikalische Chemie and Georg-August-Universität Göttingen
2002 - 2009   Research Group Leader, Department of Cellular Biochemistry, Max-PlanckInstitut für Biophysikalische Chemie, Göttingen (tenured in 2007)
2002 - 2008   Lecturer (Privatdozent), Technische Universität München
1997 - 2002   Postdoctoral fellow with Robert Huber, Max-Planck-Institut für Biochemie, Martinsried
1996              Postdoctoral research fellow with Muttaiya Sundaralingam, The Ohio State University

Coordinating Functions and Editorial Work

2014 - 2015   Member of the Organizing Committee, 40. FEBS Congress “The Biochemical Basis of Life“, 2015, Berlin
2013 -            Co-Speaker of the Einstein Network “Single Molecule RNA Biology - Dynamics and Function of RNA from Transcription to Degradation“
2011 -            Member of the Executive Committee of the Collaborative Research Center 958 “Scaffolding of Membranes - Molecular Mechanisms and Cellular Functions“
2009 -            Founding Member “Joint Berlin MX Laboratory“

  1. Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Marco Preussner M, Heyd F, Urlaub H, Lührmann R, Santos KF, Wahl MC (2015) The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes Dev doi:10.1101/gad.271528.
  2. Liu S, Mozaffari-Jovin S, Wollenhaupt J, Santos KF, Theuser M, Dunin-Horkawicz S, Fabrizio P, Bujnicki JM, Lührmann R, Wahl MC (2015) A composite, double-stranded/single-stranded RNAbinding region in the Prp3 protein important for U4/U6•U5 tri-snRNP stability and splicing. eLife 4:e07320.
  3. Mozaffari Jovin S, Wandersleben T, Santos KF, Will CL, Lührmann R, Wahl MC (2013) Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341:80-84.
  4. Weber G, Cristao VF, Santos KF, Mozaffari Jovin S, Heroven AC, Holton N, Lührmann R, Beggs JD, Wahl MC (2013) Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes Dev. 27:525-540.
  5. Santos KF, Mozaffari Jovin S, Weber G, Pena V, Lührmann R, Wahl MC (2012) Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc. Natl. Acad. Sci. USA 109:17418-17423.
  6. Weber G, Trowitzsch S, Kastner B, Lührmann R, Wahl MC (2010) Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO J. 29:4172-4184.
  7. Pena V, Mozaffari Jovin S, Fabrizio P, Orlowski J, Bujnicki JM, Lührmann R, Wahl MC (2009) Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Mol. Cell 35:454-466.
  8. Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC (2008) CASK functions as a Mg2+-independent neurexin kinase. Cell 133:328-339.
  9. Liu S, Li P, Dybkov O, Nottrott S, Hartmuth K, Lührmann R, Carlomagno T, Wahl MC (2007) Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science 316:115-120.
  10. Diaconu M, Kothe U, Schlünzen F, Fischer N, Harms J, Tonevitski AG, Stark H, Rodnina MV, Wahl MC (2005) Structural basis for the function of the ribosomal L7/12-stalk in factor binding and activation of GTP hydrolysis. Cell 121:991-1004.