Functional characterization of the molecular timer of the circadian clock of Neurospora crassa. The core negative feedback loop of the circadian clock of Neurospora is composed of the transcription activator WCC and its inhibitor complex FRQ-FRH-CK1a (FFC). We will characterize the ATP- and phosphorylation-dependent switches regulating the functional and physical interplay of the intrinsically unfolded circadian scaffold protein FRQ, the kinase CK1a and the RNA helicase FRH. Mathematical modeling will help elucidating how feedbacks synergize to generate sustained limit cycle oscillations and how molecular hourglass timers are synchronized to coordinate physiological outputs.


Prof. Dr. Michael Brunner (BZH Heidelberg)
Prof. Dr. Hans-Peter Herzel (Charité Berlin)