Prof. Dr. Volker Haucke

VolkerHaucke

Leibniz Institut für Molekulare Pharmakologie (FMP)
& Freie Universität Berlin
Institut für Pharmazie,
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49 (30) 947 93 100
Fax: +49 (30) 947 93 109
E-mail: haucke@fmp-berlin.de


Research Area

Molecular Pharmacology


Position and Status

Professor of Molecular Pharmacology (S-W3), Director of the Leibniz Institut für Molekulare Pharmakologie (FMP)


Scholarships and awards

2025 - Ernst Schering Prize for breakthroughs in lipid roles in cell communication

2020 - Feldberg Prize for Research in Physiology and Pharmacology (announced, prize will be given in 2020)
2017 - Elected Member of The German National Academy of Sciences, Leopoldina
2017 - Avanti Award of the American Society for Biochemistry & Molecular Biology (ASBMB)
2016 - Reinhart-Koselleck-Project of the DFG
2014 - Elected Member of the European Molecular Biology Organization (EMBO)
2003 - Young Investigator Award (YIP), European Molecular Biology Organization (EMBO)
1998 - 1999 - Long-Term Fellowship Award, Human Frontier Science Program
1997 - 1998 - Long-Term Fellowship Award, European Molecular Biology Organization
1995 - Short-Term Fellowship Award, European Molecular Biology Organization
1994 - 1997 - Boehringer Ingelheim Fellow
1993 - 1994 - Dr. Carl-Duisberg-Foundation Scholar
1990 - 1994 - Scholarship Holder of the Studienstiftung des deutschen Volkes



University training and degree

1994 - Diploma in Biochemistry, Freie Universität Berlin
04/1989 - 02/1994 - Study of Biochemistry at Freie Universität Berlin & Univ. of Basel

 

Advanced academic qualifications

2003 - Habilitation (venia legendi) in Biochemistry, Georg-August-Universität Göttingen
1997 - Ph.D. in Biochemistry, Biozentrum, Univ.of Basel (summa cum laude; supervisor: Prof. Dr. G. Schatz)

 

Postgraduate professional career

01/2012 - present - Full Professor of Molecular Pharmacology (S-W3), Freie Universität Berlin & Director of the Leibniz-Institut für Molekulare Pharmakologie; Faculty Member Charité University Medicine Berlin
09/2005 - 12/2011 - Full Professor of Biochemistry (W3), FU Berlin, Institute of Chemistry & Biochemistry, Department of Membrane Biochemistry & Charité Universitätsmedizin Berlin
10/2003 - 08/2005 - Professor of Biochemistry (C3), FU Berlin, Institute of Chemistry & Biochemistry, Department of Membrane Biochemistry
05/2000 - 09/2003 - Head of Independent DFG Junior Research Group, University of Göttingen
04/1997 - 04/2000 - Postdoctoral fellow, Yale University & HHMI (w/ Prof. Pietro De Camilli)

Coordinating functions and editorial work

2021 – present - Vice-President, German Society for Biochemistry & Molecular Biology (GBM)

2017 - present - Scientific Advisory Board, Leibniz Institute on Aging-Fritz Lipmann Institute (FLI)
2015 - present - Scientific Advisory Board of open access platform Matters
2012 - present- Editorial Board Member, EMBO Reports
2007 - 2012 - Editorial Board Member, The Journal of Biological Chemistry
since 2005 - Editorial Board Member, Biology of the Cell
since 2006 - Member, Faculty of 1000, Neuronal Signaling
2008 - 2016 - Member, Study Section, "Biochemistry“ of the German Funding Agency (DFG)
since 2007 - Member & Principal Investigator, NeuroCure Cluster of Excellence
since 2011 - Founding-Chair (now vice-chair) & Member, SFB 958 "Scaffolding of Membranes"
2008 - 2010 - Chair, SFB 449 "Structure and Function of Membrane Integral Receptors"

Most important publications

  1. Ebner, M., Puchkov, D., López-Ortega, O., Muthukottiappan, P., Su, Y., Schmied, C., Zillmann, S., Nikonenko, I., Koddebusch, J., Dornan, G. L., Lucht, M. T., Koka, V., Jang, W., Koch, P. A., Wallroth, A., Lehmann, M., Brügger, B., Pende, M., Winter, D. & Haucke, V. Nutrient-regulated control of lysosome function by signaling lipid conversion. Cell (2023). DOI: 10.1016/j.cell.2023.09.027
  2. Rizalar, F. S., Lucht, M. T., Petzoldt, A., Kong, S., Sun, J., Vines, J. H., Telugu, N. S., Diecke, S., Kaas, T., Bullmann, T., Schmied, C., Löwe, D., King, J. S., Cho, W., Hallermann, S., Puchkov, D., Sigrist, S. J. & Haucke, V. Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly. Science 382, 223-230 (2023). DOI:10.1126/science.adg1075
  3. Jang, W., Puchkov, D., Samsó, P., Liang, Y., Nadler-Holly, M., Sigrist, S. J., Kintscher, U., Liu, F., Mamchaoui, K., Mouly, V. & Haucke, V. Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function. Science 378, eabq5209 (2022). DOI:10.1126/science.abq5209
  4. Lo, W.-T., Zhang, Y., Vadas, O., Roske, Y., Gulluni, F., De Santis, M. C., Zagar, A. V., Stephanowitz, H., Hirsch, E., Liu, F., Daumke, O., Kudryashev, M. & Haucke, V. Structural basis of phosphatidylinositol 3-kinase C2α function. Nature Structural & Molecular Biology 29, 218-228 (2022). https://doi.org/10.1038/s41594-022-00730-w
  5. Kuijpers, M., Kochlamazashvili, G., Stumpf, A., Puchkov, D., Swaminathan, A., Lucht, M. T., Krause, E., Maritzen, T., Schmitz, D. & Haucke, V. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron 109, 299-313.e299 (2021). DOI: 10.1016/j.neuron.2020.10.005
  6. López-Hernández, T., Puchkov, D., Krause, E., Maritzen, T. & Haucke, V. Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis. Nature Cell Biology 22, 815-827 (2020). https://doi.org/10.1038/s41556-020-0535-7
  7. Marat, A. L., Wallroth, A., Lo, W.-T., Müller, R., Norata, G. D., Falasca, M., Schultz, C. & Haucke, V. mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. Science 356, 968-972 (2017). DOI:10.1126/science.aaf8310
  8. Ketel, K., Krauss, M., Nicot, A.-S., Puchkov, D., Wieffer, M., Müller, R., Subramanian, D., Schultz, C., Laporte, J. & Haucke, V. A phosphoinositide conversion mechanism for exit from endosomes. Nature 529, 408-412 (2016). https://doi.org/10.1038/nature16516
  9. Posor, Y., Eichhorn-Gruenig, M., Puchkov, D., Schöneberg, J., Ullrich, A., Lampe, A., Müller, R., Zarbakhsh, S., Gulluni, F., Hirsch, E., Krauss, M., Schultz, C., Schmoranzer, J., Noé, F. & Haucke, V. Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature 499, 233-237 (2013). https://doi.org/10.1038/nature12360
  10. Lisa, Stahlschmidt, W., Bulut, H., Gromova, K., Puchkov, D., Mark, Kylie, Tomilin, N., Pechstein, A., Chau, N., Chircop, M., Sakoff, J., Jens, Saenger, W., Kräusslich, H.-G., Shupliakov, O., Phillip, McCluskey, A. & Haucke, V. Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition. Cell 146, 471-484 (2011). DOI: 10.1016/j.cell.2011.06.025