Prof. Dr. Georg Stoecklin

Prof. Dr. Georg Stoecklin

Abteilung Biochemie I
Medizinische Fakultät Mannheim der Universität Heidelberg
Centrum für Biomedizin und Medizintechnik Mannheim (CBTM)
Ludolf-Krehl-Str. 13 – 17
68167 Mannheim
Temporary phone: +49 (6221) 54-6887
Temporary fax: +49 (6221) 54-6891
Temporary E-mail: g.stoecklin@dkfz.de


Research Area

Biochemistry, Molecular Biology, Cell Biology


Position and Status

Professor W3 for Biochemistry


Scholarships and awards

2002 - 2004    Postdoctoral Fellowship, Swiss National Science Foundation
2001               Paul Basset Prize, European Cancer Center Meeting, Strasbourg, France
2000               Roche Research Foundation Award, Switzerland
1997 - 2000    M.D./Ph.D. Fellowship, Swiss Academy of Medical Sciences
1996               Medical Faculty Prize, University of Basel, Switzerland
1990               Prix Ernest Leuba, University of Neuchâtel, Switzerland



Academic Education

1997 - 2000   Ph.D. thesis with Christoph Moroni, Institute for Medical Microbiology, M.D./Ph.D. Program, University of Basel, Switzerland
1990 - 1997   Medical School, University of Basel, Switzerland 1989 – 1990 Medical School, University of Neuchâtel, Switzerland

 

University Degrees

16/01/2013 Habilitation (venia legendi) in Molecular Biology, Ruprecht Karls Universität Heidelberg, Germany
05/04/2000 Ph.D. in Biology (Dr. phil. II), University of Basel, Switzerland
16/01/1997 M.D. (Dr. med.) University of Basel, Switzerland
19/11/1996 Medical Licensing Exam (Staatsexamen) University of Basel, Switzerland

 

Employment

2016 -            Professor for Biochemistry, Medical Faculty Mannheim at Heidelberg University
2006 - 2015   Junior Group Leader, German Cancer Research Center (DKFZ) and Center for Molecular Biology at Heidelberg University (ZMBH)
2004 - 2006   Instructor of Medicine, Harvard Medical School, Boston, USA
2002 - 2004   Postdoctoral Fellow with Paul Anderson, Brigham and Women’s Hospital, Boston, MA, USA
2000 - 2001   Postdoctoral Fellow with Christoph Moroni, Institute of Medical Microbiology, University of Basel, Switzerland

Coordinating Functions and Editorial Work

2013     Guest Editor, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
2012     Speaker of the Emerging Collaborative Topic 5 "Non-coding RNAs as versatile regulators of cellular processes" within the CellNetworks Excellence Cluster, University of Heidelberg
2011 -   Academic Editor, PLoS One

  1. Schott J, Reitter S, Philipp J, Haneke K, Schäfer H, Stoecklin G (2014) Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation. PLoS Genet 10:e1004368.
  2. Schleich S, Strassburger K, Janiesch PC, Koledachkina T, Miller KK, Haneke K, Cheng Y-S, Küchler K, Stoecklin G, Duncan KE, Teleman AA (2014) DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. Nature 512:208-12.
  3. Cherkasov V, Hofmann S, Druffel-Augustin S, Mogk A, Tyedmers J, Stoecklin G, Bukau B. (2013) Coordination of translational control and protein homeostasis during severe heat stress. Curr Biol 23:2452-62.
  4. Leppek K, Schott J, Reitter S, Poetz F, Hammond MC, Stoecklin G (2013) Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs. Cell 153:869-81.
  5. Hofmann S, Cherkasova V, Bankhead P, Bukau B, Stoecklin G (2012) Translation suppression promotes stress granule formation and cell survival in response to cold shock. Mol Biol Cell 23:3786-800.
  6. Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R. (2012) Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 12:71-85.
  7. Spasic M, Friedel CC, Schott J, Kreth J, Leppek K, Hofmann S, Ozgur S, Stoecklin G. (2012) Genome-wide assessment of AU-rich elements by the AREScore algorithm. PLoS Genet 8:e1002433.
  8. Ozgur S, Chekulaeva M, Stoecklin G. (2010) Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing-bodies. Mol Cell Biol 30:4308-23.
  9. Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WFC, Blackwell TK, Anderson P (2004) MK2- induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J 23:1313-24.
  10. Stoecklin G, Colombi M, Raineri I, Leuenberger S, Mallaun M, Schmidlin M, Gross B, Lu M, Kitamura T, Moroni C (2002) Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J 21:47099-18.