Effect of membrane lipid phosphorylation on protein recruitment at molecular and cellular scales. Selective phosphorylation/dephosphorylation of phosphoinositide lipids via kinases and phosphatases are important regulators of cellular functions such as intracellular trafficking, cell growth and differentiation. The changes induced into the membrane on the atomistic scale by phosphorylation act as molecular switches for processes at the cellular level. In this project will use molecular dynamics, Markov state modeling and reaction-diffusion simulation to assess the effects of membrane phosphorylation on the atomistic and cellular scale and establish relationships between the two scales.


Prof. Dr. Frank Noé (FU Berlin)
Dr. Nuria Plattner (FU Berlin)