Prof. Dr. Thomas Söllner

Biochemie-Zentrum der Universität Heidelberg (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
Phone: +49 (6221) 54-5342
Fax: +49 (6221) 54-5341
E-mail: thomas.soellner@bzh.uni-heidelberg.de


Research Area

Molecular Cell Biology, Biochemistry, Neurobiology


Position and Status

Professor (W3)


Scholarships and awards

1991 - 1993    Postdoctoral fellowship (DFG)
1991               Ph.D. with the grade: summa cum laude



Academic Education

01/1987 - 07/1991   Ph.D. thesis at the Institute for Physiological Chemistry, Ludwig-MaximiliansUniversity Munich, supervised by Prof. Dr. Dr. Walter Neupert
01/1986 - 12/1986   Diploma thesis at the Institute of Genetics and Microbiology, LudwigMaximilians-University, Munich, supervised by Prof. Dr. Rudolf Schweyen
11/1982 - 12/1986   Study of Biology at the Ludwig-Maximilians-University, Munich
11/1980 - 10/1982   Study of Biology at the University of Regensburg

 

University Degrees

1991   Ph.D. degree, Biology, Ludwig-Maximilians-University Munich Mentor: Prof. Dr. Dr. Walter Neupert
1987   Diploma in Biology, Ludwig-Maximilians-University Munich Mentor: Prof. Dr. Rudolf Schweyen

 

Employment

09/2005 -                 Full Professor at Heidelberg University Biochemistry Center, Faculty of Medicine
11/2000 - 09/2005   Associate Member, Cell Biology Program, Sloan Kettering Institute, New York
08/2003 - 10/2004   Assistant Member, Cell Biology Program, Sloan Kettering Institute, New York
01/1998 - 07/2003   Assistant Member, Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, New York
01/1994 - 12/1997   Assistant Laboratory Member with Prof. Dr. James E. Rothman, Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, New York
08/1991 - 12/1993   Research Fellow with Prof. Dr. James E. Rothman, Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, New York

Editorships

2013 -            Associate Editor, The Journal of Biological Chemistry
2007 - 2012   Editorial Board Member, The Journal of Biological Chemistry
2010 -            Speaker of the Transregional Collaborative Research Centre 83 "Molecular Architecture and Cellular Functions of Lipid/Protein Assemblies"

  1. Bharat, T.A.M., Malsam, J., Hagen, W.J.H., Scheutzow, A., Söllner, T.H., Briggs, J.A.G. (2014) SNAREs and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium‐triggered fusion. EMBO Reports 15: 308–314.
  2. Parisotto, D., Pfau, M., Scheutzow A., Wild, K., Mayer, M.P., Malsam, J., Sinning, I., and Söllner, T.H. (2014) An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (Soluble N -Ethylmaleimide-sensitive Factor Attachment Protein Receptor) complex assembly. J. Biol. Chem. 289: 9639-9650.
  3. Malsam, J., Parisotto, D., Bharat, T.A.M., Scheutzow, A., Krause, J.M., Briggs, J.A.G., and Söllner, T.H. (2012) Complexin arrests a pool of docked vesicles for Ca2+-dependent release. EMBO J. 31: 3270-3281.
  4. Mahal, L.K., Sequeira, S.M., Gureasko, J., and Söllner, T.H. (2002) Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I. J.Cell Biol 158: 273- 282.
  5. Fukuda, R., McNew, J.A., Weber, T., Parlati, F., Engel, T., Nickel, W., Rothman, J.E., and Söllner, T.H. (2000) Functional architecture of an intracellular membrane t-SNARE. Nature 407:198-202.
  6. McNew, J.A., Parlati, F., Fukuda, R., Johnston, R.J., Paz, K., Paumet, F., Söllner, T.H., and Rothman, J.E. (2000) Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature 407:153-159.
  7. Weber, T., Zemelman, B.V., McNew, J.A., Westermann, B., Gmachl, M., Parlati, F., Söllner, T.H., and Rothman, J.E. (1998) SNAREpins: minimal machinery for membrane fusion. Cell 92:759-772.
  8. Söllner, T., Whiteheart, S.W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., and Rothman, J.E. (1993) SNAP receptors implicated in vesicle targeting and fusion. Nature 362:318-324.
  9. Söllner, T., Rassow, J., Wiedmann, M., Schlossmann, J., Keil, P., Neupert, W. and Pfanner, N. (1992) Mapping of the mitochondrial protein import machinery by stage specific cross-linking of translocation intermediates. Nature 355:84-87.
  10. Söllner, T., Griffiths, G., Pfaller, R., Pfanner, N., and Neupert, W. (1989) MOM19, an import receptor for mitochondrial precursor proteins. Cell 59:1061-1070.