Spatio-temporal control of CD95-activation mode. CD95 is a transmembrane receptor that upon binding to CD95L induces apoptosis or survival signals. To induce apoptosis a death inducing signaling complex including adaptor proteins and initiator caspases is assembled to the CD95 intracytoplasmic death domain (DD). Induction of Kinase activity occurs through binding of SH2-containing proteins to an immune-tyrosine-like domain (ITIM/ITAM-like) located within the very same death domain. This project aims at understanding the spatio-temporal control of the caspase/kinase switch in glioblastoma cells using advanced microscopy and chemical biology tools. The final goal is to convert CD95-tumorigenic signals into death ones in tumor cells.


Prof. Dr. Ana Martin-Villalba (DKFZ Heidelberg)
Prof. Dr. Helge Ewers (FU Berlin)