Dr. Alexander Matthias Walter

Leibniz Institut für Molekulare Pharmakologie (FMP)
FMP im ChariteCrossOver (CCO)
Intern: Virchowweg 6, Raum 05 217
Chariteplatz 1
10117 Berlin
Phone: +49 (30) 450 639026
E-mail: awalter@fmp-berlin.de


Research Area

Molecular Neuroscience, Biophysics, Mathematical Modeling


Position and Status

Emmy Noether Junior Research Group Leader


Scholarships and awards

2015 -             Member of the executives network “Genshagener Kreis”
2015 -             Emmy Noether research grant, German Science Foundation (DFG), Bonn, Germany
2010 - 2011    EMBO Long-term Fellowship, European Molecular Biology Organization
2009               Invitation to the 59th Meeting of Noble Laureates, Lindau, Germany
2008               Excellence in Teaching Neuroscience, award for best teaching (tutorial), International Max Planck Research School, Göttingen, Germany
2007               Symposium Award of the Society for General Physiologists
2005 - 2006    DAAD Scholarship for graduate students, “Deutscher Akademischer Austauschdienst”, Bonn, Germany
2004 - 2005    Scholarship Max Planck Research School, Göttingen, Germany



Academic Education

08/2006 - 10/2009   Dr. rer. nat., Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. (Thesis advisors: Jakob Sørensen, Erwin Neher, Reinhard Jahn)
08/2004 - 07/2006   International Max Planck Research School Neuroscience Göttingen, Germany
10/2001 - 07/2004   Study of Chemistry, Georg-August University, Göttingen, Germany

 

University Degrees

2009   Dr. rer. nat., International Max Planck Research School & Max Planck Institute for Biophysical Chemistry, Göttingen, Germany - dissertation grade: summa cum laudae
2006   Master of Science, International Max Planck Research School & Karolinska Institute, Stockholm, Sweden - grade: A, top of the class
2003   Vordiplom, Department of Chemistry, Georg August Universtity Göttingen - grade “Sehr gut” (excellent)

 

Employment

03/2015 -                 Emmy Noether group leader, Molecular and Theoretical Neuroscience, Leibniz Institute for Molecular Pharmacology, Berlin, Germany
08/2013 - 02/2015   Post-doc with Stephan Sigrist and Volker Haucke, Neurocure Cluster of Excellence, Charité Berlin, Germany
08/2011 - 05/2013   Post-doc with Jakob Sørensen, Department of Neurosciences and Pharmacology, University of Copenhagen, Denmark
01/2010 - 07/2011   Post-doc with Matthijs Verhage, Center of Neurogenomics and Cognitive Research, Free University of Amsterdam, The Netherlands

  1. Man, K. M., Imig, C., Walter, A. M., Pinheiro, P. S., Stevens, D. R., Rettig, J., Sorensen, J. B., Cooper, B. H., Brose, N., and Wojcik, S. M. (2015) Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Elife 4, pii: e10635. doi: 10.7554/eLife.10635. [Epub ahead of print].
  2. Muhammad, K., Reddy-Alla, S., Driller, J. H., Schreiner, D., Rey, U., Bohme, M. A., Hollmann, C., Ramesh, N., Depner, H., Lutzkendorf, J., Matkovic, T., Gotz, T., Bergeron, D. D., Schmoranzer, J., Goettfert, F., Holt, M., Wahl, M. C., Hell, S. W., Scheiffele, P., Walter, A. M., Loll, B., and Sigrist, S. J. (2015) Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Nat Commun 6:8362.
  3. Schotten, S.*, Meijer, M.*, Walter, A. M.*, Huson, V., Mamer, L., Kalogreades, L., ter Veer, M., Ruiter, M., Brose, N., Rosenmund, C., Sorensen, J. B., Verhage, M., and Cornelisse, L. N. (2015) Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate. Elife 4, e05531.
  4. Walter, A. M., Kurps, J., de Wit, H., Schoning, S., Toft-Bertelsen, T. L., Lauks, J., Ziomkiewicz, I., Weiss, A. N., Schulz, A., Fischer von Mollard, G., Verhage, M., and Sorensen, J. B. (2014) The SNARE protein vti1a functions in dense-core vesicle biogenesis. EMBO J. 33:1681-1697.
  5. Kononenko, N. L., Puchkov, D., Classen, G. A., Walter, A. M., Pechstein, A., Sawade, L., Kaempf, N., Trimbuch, T., Lorenz, D., Rosenmund, C., Maritzen, T., and Haucke, V. (2014) Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses. Neuron 82:981-988.
  6. Walter, A. M.^, Haucke, V., and Sigrist, S. J. (2014) Neurotransmission: spontaneous and evoked release filing for divorce. Curr. Biol. 24:R192-194.
  7. Walter, A. M.^, Pinheiro, P. S., Verhage, M., and Sorensen, J. B. (2013) A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion. PLoS Comput. Biol. 9, e1003362.
  8. Walter, A. M., Groffen, A. J., Sorensen, J. B., and Verhage, M. (2011) Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats? Trends Neurosci. 34:487-497.
  9. Walter, A. M., Wiederhold, K., Bruns, D., Fasshauer, D., and Sorensen, J. B. (2010) Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis. J. Cell Biol. 188:401-413.
  10. de Wit, H., Walter, A. M., Milosevic, I., Gulyas-Kovacs, A., Riedel, D., Sorensen, J. B., and Verhage, M. (2009) Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell 138:935-946.

*: equal contribution, ^: corresponding author