Prof. Dr. Michael Boutros

Prof. Dr. Michael Boutros

Ruprecht-Karls-Universität Heidelberg &
Deutsches Krebsforschungszentrum (DKFZ)
Dept. of Cell and Molecular Biology
Ludolf-Krehl-Strasse 13-17
68167 Mannheim
Phone: +49 (6221) 42-1951
Fax: +49 (6221) 42-1959

Research Area

Cell Biology, Developmental Genetics, Genome Biology

Position and Status

Professor for Cell and Molecular Biology (W3), Head of Division

Scholarships and awards

2013               Elected EMBO Member
2012               ERC Advanced Grant
2007               Johann-Georg Zimmermann Award for Cancer Research
2003               EMBO Young Investigator Award
2001 - 2003    Emmy-Noether Postdoctoral Fellowship (DFG)
1996 - 1999    Boehringer Ingelheim PhD fellowship
1991 - 1999    Fellow of the Studienstiftung des deutschen Volkes

Academic Education

10/1996 - 07/1999   Ph.D. thesis with Marek Mlodzik at EMBL and Heidelberg University, Heidelberg
10/1995 - 08/1996   Diploma thesis with Winship Herr at Cold Spring Harbor Laboratory, New York, USA
10/1993 - 08/1996   Study of Biochemistry at Witten/Herdecke University, Witten
10/1991 - 10/1993   Study of Biology at RWTH Aachen, Aachen


University Degrees

1999   Ph.D. in Molecular Biology, EMBL and Heidelberg University, Mentor: Marek Mlodzik
1996   Diploma in Biochemistry, Witten/Herdecke University



09/2015 - present   Scientific Director (interim), German Cancer Research Center (DKFZ), Heidelberg
10/2008 - present   Professor of Cell and Molecular Biology, Heidelberg University
10/2008 - present   Head of Division, German Cancer Research Center (DKFZ), Heidelberg
07/2003 - 12/2007  Group leader in the Emmy-Noether Program at the DKFZ, Heidelberg
08/1999 - 06/2003  Postdoctoral research fellow with Norbert Perrimon at Harvard Medical School, Boston, USA

Coordinating Functions and Editorial Work

2014 -               Editorial Board Member, Molecular Systems Biology
2012 -               Member of the Board (Kuratorium), Studienstiftung des deutsche Volkes
2012 -               Member of the Executive Board and PI, Excellence Cluster CellNetworks, Heidelberg University
2008 -               Member of the Executive Board and PI, Excellence Graduate School HBIGS, Heidelberg University
2010 - 2014      Elected Member of the Senate of Heidelberg University
2008 - 2011      Coordinator of the FP7 project "CancerPathways"

  1. Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C, Boutros M (2013) RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Rep 4: 1224-1234
  2. Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, Moffa G, Hundsrucker C, Kerr G, Sandmann T, Anchang B, Demir K, Boehm C, Leible S, Ball CR, Glimm H, Spang R, Boutros M. (2013) Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun 4: 2610
  3. Gross JC, Chaudhary V, Bartscherer K, Boutros M (2012) Active Wnt proteins are secreted on exosomes. Nat Cell Biol 14: 1036–1045
  4. Buechling T, Chaudhary V, Spirohn K, Weiss M, Boutros M (2011) p24 proteins are required for secretion of Wnt ligands. EMBO reports 12: 1265–1272
  5. Horn T, Sandmann T, Fischer B, Axelsson E, Huber W, Boutros M (2011) Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nature Methods 8: 341–346
  6. Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C, Boutros M (2010) Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr Biol 20: 1263–1268
  7. Fuchs F, Pau G, Kranz D, Sklyar O, Budjan C, Steinbrink S, Horn T, Pedal A, Huber W, Boutros M (2010) Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol 6: 370
  8. Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M, Niehrs C (2010) Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 327: 459–463
  9. Bartscherer K, Pelte N, Ingelfinger D, Boutros M (2006) Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125: 523–533
  10. Müller P, Kuttenkeuler D, Gesellchen V, Zeidler MP, Boutros M (2005) Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 436: 871–875