Prof. Dr. Britta J. Eickholt

Prof. Dr. Britta J. Eickholt

Charité – Universitätsmedizin Berlin
Institut für Biochemie
Virchowweg 6
10117 Berlin
Phone: +49 (0)30 450 539121
Fax: +49 (0)30 450 7539121
E-mail: Britta.Eickholt@charite.de


Research Area

Cell Signaling, Neuronal Cell Biology, Cytoskeleton, Biochemistry


Position and Status

Professor (W3)


Scholarships and awards

2000 - 2001    KCL IRG Research Fellowship, King’s College London



Academic Education

01/1995 - 05/1998   Ph.D. in Biochemistry, King’s College London, London (Advisor: Prof. P. Doherty and Prof. F. Walsh)
05/1993 - 05/1994   Diploma thesis, Max-Planck Institute for Developmental Biology, Tübingen (Advisor: Prof. E. Pollerberg), distinction
10/1989 - 04/1993   Study of Biology (Cell Biology, Biochemistry, Genetics, Microbiology) Eberhard-Karls-University Tübingen, first class honors

 

University Degrees

2011   Professor (W3) for Cellular and Molecular Biochemistry, Charite - Universitätsmedizin Berlin
2010   Professor for Molecular and Cellular Neurobiology, King’s College London
1998   Ph.D. in Biochemistry, King’s College London, London (Advisor: Prof. P. Doherty and Prof. F. Walsh)
1994   Diploma thesis, Max-Planck Institute for Developmental Biology, Tübingen (Advisor: Prof. E. Pollerberg), distinction
1993   Diploma in Biology (Cell Biology, Biochemistry, Genetics, Microbiology) Eberhard-Karls-University Tübingen, Germany; first class honors

 

Employment

07/2011 -       Professor (W3) for Cellular and Molecular Biochemistry, Charite – Universitätsmedizin Berlin
2001 - 2011   Principle Investigator, MRC Centre for Developmental Neurobiology, King’s College London, London, UK (Institute Head: Prof. A. Lumsden)
1998 - 2000   Postdoctoral Researcher, Molecular Neurobiology Group, King’s College London
1994 - 1995   Temporary Research Position, Laboratory of Prof. A. Lumsden, Guy’s Hospital, London


 

Coordinating Functions and Editorial Work

2015    Review Editor Frontiers in Molecular Neuroscience

  1. Spinelli L, Black FM, Berg JN, Eickholt BJ, Leslie NR. (2015) Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes. J Med Genet. 52:128-34.
  2. Kreis P, Leondaritis G, Lieberam I, Eickholt BJ. (2014) Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders. Front Mol Neurosci. 7:23.
  3. Kreis P, Hendricusdottir R, Kay L, Papageorgiou IE, van Diepen M, Mack T, Ryves J, Harwood A, Leslie NR, Kann O, Parsons M, Eickholt BJ. (2013) Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN. PLoS One. 8(8):e71957
  4. Berglund FM, Weerasinghe NR, Davidson L, Lim JC, Eickholt BJ, Leslie NR (2013) Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110alpha/PIK3CA but not by HER2 or mutant AKT1. Oncogene 32:4417-26 .
  5. Kay L., Humphreys L., Eickholt BJ and Burrone J. (2011) Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation. Nat Neurosci 14:688-90.
  6. Van Diepen MT, Parsons M., Downes CP, Leslie, NR, Hindges R. and Eickholt BJ (2009) MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol 11:1191-6.
  7. Cosker, KE, Shadan S., van Diepen M., Morgan C., Li M., Allen-Baume V., Hobbs C., Doherty P, Cockcroft S and Eickholt BJ (2008) Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal neurons. J Cell Sci 121:796-803.
  8. Eickholt BJ, Ahmed, AI, Davies M., Papakonstanti EA, Pearce W, Starkey ML, Bilancio A, Need AC, Smith AJ, Hall SM et al. (2007) Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase. PLoS One 2, e869.
  9. Chadborn NH, Ahmed AI, Holt MR, Prinjha R, Dunn GA, Jones GE and Eickholt BJ (2006) PTEN couples Sema3A signalling to growth cone collapse. J Cell Sci 119:951-957.
  10. Eickholt BJ*, Walsh FS and Doherty P (2002) An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J Cell Biol 157:211-7. *corresponding author