Dr. Andrew Plested

Leibniz-Institut für Molekulare Pharmakologie (FMP) &
Cluster of Excellence NeuroCure,
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49 (30) 9406-3071
Fax: +49 (30) 9406-2960
E-mail: plested@fmp-berlin.de

Research Area

Biophysics, Structural Biology, Neuroscience

Position and Status

Junior Group Leader

Scholarships and awards

2015   Visiting Scholar, Initiative d’Excellence, University of Bordeaux
2015   ERC Consolidator Grant
2008   Wellcome Trust Research Career Development Fellowship declined
2008   MRC Career Development Award declined
2008   Fellows award in research excellence, NIH

Academic Education

10/1998 - 09/2002   Ph.D. thesis with Nick Franks and Bill Lieb at Imperial College London
10/1994 - 06/1998   Master of Science Degree in Physics, Imperial College London


University Degrees

01/2003   Ph.D. in Molecular Biosciences, Imperial College, University of London



11/2008 -                 Junior Group Leader at the FMP-Berlin and member of the Cluster of Excellence NeuroCure
11/2005 - 11/2008   Postdoctoral research fellow with Mark Mayer at NIH, USA
02/2003 - 10/2005   Postdoctoral research fellow with David Colquhoun FRS at UCL, UK

Coordinating Functions and Editorial Work

2014 -   Editor, Biophysical Journal
2010 -   Executive Editor, Neuropharmacology

  1. Carbone AL and Plested AJR (2016) Superactivation of AMPA receptors by auxiliary proteins. Nature Communications, http://www.nature.com/ncomms/2016/160108/ncomms10178/full/ncomms10178.html.
  2. Klippenstein V, Ghisi V, Wietstruk M and Plested AJR (2014) Photoinactivation of glutamate receptors by a genetically encoded unnatural amino acid. Journal of Neuroscience 34:980-991.
  3. Lau AY†*, Salazar H†, Blachowitz L, Ghisi V, Plested AJR*, Roux B* (2013) A conformational intermediate in glutamate receptor activation. Neuron 79:492-503. †These authors contributed jointly. *Corresponding authors
  4. Miranda P, Contreras JE, Plested AJR, Sigworth FJ, Holmgren M, and Giraldez T (2013) Statedependent FRET reports calcium and voltage-dependent gating-ring motions in whole BK channels. Proc. Natl. Acad. Sci. U.S.A. 110:5217-22.
  5. Carbone AL and Plested AJR (2012) Coupled control of desensitization and gating by the ligand binding domain of glutamate receptors. Neuron 74:845–857.
  6. Lape R*, Plested AJR*, Moroni M, Colquhoun D and Sivilotti LG (2012) The α1K276E startle disease mutation reveals multiple intermediate states in the gating of glycine receptors. Journal of Neuroscience 32:1336-52. *These authors contributed jointly.
  7. Das U, Kumar J, Mayer ML* and Plested AJR* (2010) Domain organization and function in GluK2 subtype kainate receptors. Proc. Natl. Acad. Sci. U.S.A. 107:8463-8. *Corresponding authors
  8. Plested AJR, and Mayer ML (2009) AMPA receptor ligand binding domain mobility revealed by functional crosslinking. Journal of Neuroscience 29:11912-23.
  9. Plested AJR*, Vijayan R*, Biggin PC and Mayer ML (2008) Molecular basis of kainate receptor modulation by sodium. Neuron 58:720-35. *These authors contributed jointly.
  10. Plested AJR and Mayer ML (2007) Structure and mechanism of anion modulation of kainate receptors. Neuron 53: 829-41.