Dr. Anne-Claude Gavin


European Molecular Biology Laboratory (EMBL)
Structural Biology
Meyerhofstrasse 1
69117 Heidelberg
Phone: +49 (6221) 387-8816
Fax: +49 (6221) 387- 8519
E-mail: gavin@embl.de

Research Area

Biochemistry, Mass Spectrometry, Network Biology, Systems Biology,
Molecular Cell Biology

Position and Status

Group Leader and Senior Scientist

Scholarships and awards

2010              Heidelberg Molecular Life Sciences (HMLS) Investigator Award; 100,000 €
2002              Genome Technology All-Stars Award “Most Prolific in Proteomics”
1996 - 1999   Postdoctoral fellowship from the Swiss National Science Foundation (SNSF)

Academic Education

1987 - 1992   Ph.D. thesis with Sabine Schorderet-Slatkine at the University of Geneva, CH
1986 - 1987   Diploma thesis with Charles Thiebaud at the Station of Experimental Zoology, University of Geneva, CH
1982 - 1986   Study of Biology at the University of Geneva, CH


University Degrees

1992   Ph.D. in Biology, Faculty of Science, University of Geneva



07/2011 -                 Senior Scientist at the Structural and Computational Biology Unit, EMBL Heidelberg
11/2005 -                 Group Leader at the Structural and Computational Biology Unit, EMBL Heidelberg
05/2000 - 10/2005   Scientific director Molecular and Cellular Biology, Cellzome AG, Heidelberg
05/1999 - 04/2000   Associate Professor at the Department of Physiology, University of Basel, CH
05/1996 - 04/1999   Postdoctoral research fellow with Angel Nebreda at the EMBL, Heidelberg
10/1992 - 04/1996   Postdoctoral fellow with Sabine Schorderet-Slatkine at the University of Geneva, CH

2016 -            Member of the scientific advisory board for Systems Biology Ireland
2016 -            Member of the DFG review board Life sciences - Biochemistry
2014 -            Member of the Advisory Board for Molecular Systems Biology
2014 -            Elected EMBO member
2013 -            Member of the Board of Reviewing Editors for Science Signaling
2013 -            Member of the Scientific Data, NPG, Advisory Panel
2011 -            Associate Editor of Molecular and Cellular Proteomics
2011 - 2015   Member of the Allen Institute for Brain Science Cell Networks Advisory Council, Seattle, US
2011 - 2013   Editorial Board Member of Molecular BioSystems, RSC Publishing
2007 - 2011   Editorial Board Member, Molecular and Cellular Proteomics
2006              Section editor for Drug Discovery Today: Technologies on Proteomics


  1. Vonkova I., Saliba A.E., Deghou S.L., Anand K., Ceschia S., Doerks T., Galih A., Kugler K.G., Maeda K, Rybin V., van Noort V., Ellenberg J., Bork P. and Gavin A.C. (2015). Lipid cooperativity as a general membrane-recruitment principle of PH domains. Cell Rep. 12, 1519-1530.
  2. Köberlin M.S., Snijder B., Heinz L.X., Baumann C.L., Fauster A., Vladimer G.I., Gavin A.C. and Superti-Furga G. (2015). A conserved circular network of coregulated lipids modulates innate immune responses. Cell 162, 170-183.
  3. Maeda K., Poletto M., Chiapparino A. and Gavin A.C. (2014). A generic protocol for the purification and characterization of water-soluble protein–lipid complexes. Nat. Protoc. 9, 2256-66.
  4. Saliba A.E., Vonkova I., Ceschia S., Findlay G.M., Maeda K., Tischer C., Deghou S., van Noort V., Bork P., Pawson T., Ellenberg J. and Gavin A.C. (2014). A quantitative liposome microarray to systematically characterize protein-lipid interactions. Nat. Methods 11, 47-50.
  5. Maeda K., Anand K., Chiapparino A., Kumar A., Poletto M., Kaksonen M. and Gavin A.C. (2013). Interactome map uncovers phosphatidylserine transport by a family of oxysterol-binding proteins. Nature 501, 257-61.
  6. Anand K., Maeda K. and Gavin A.C. (2012). Structural analyses of Slm1-PH domain demonstrate ligand binding in the non-canonical site. PLoS One 7, e36526.
  7. van Noort V., Seebacher J, Bader S., Mohammed S., Vonkova I., Betts M.J., Kühner S., Kumar R., Maier T., O’Flaherty M., Rybin V., Schmeisky A., Yus E., Stülke J., Serrano L., Russell R.B., Heck A.J., Bork P. and Gavin A.C. (2012). Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. Mol. Syst. Biol. 8, 571.
  8. Gallego O, Betts MJ, Gvozdenovic-Jeremic J, Maeda K, Matetzki C, Aguilar-Gurrieri C, Beltran- Alvarez P, Bonn S, Fernández-Tornero C, Jensen LJ, Kuhn M, Trott J, Rybin V, Müller CW, Bork P, Kaksonen M, Russell RB and Gavin AC. (2010). A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol. Syst. Biol. 6, 430.
  9. Gehlenborg N., O’Donoghue S.I., Baliga N.S., Goesmann A., Hibbs M.A., Kitano H., Kohlbacher O., Neuweger H., Schneider R., Tenenbaum D. and Gavin A.C. (2010). Visualization of Omics Data for Systems Biology. Nat. Methods 7, S56-S68.
  10. Kühner S., van Noort V., Betts M.J., Leo-Macias A., Batisse C., Rode M., Yamada T., Maier T., Bader S., Beltran-Alvarez P., Castaño-Diez D., Chen W.H., Devos D., Güell Cargol M., Norambuena T., Racke I., Rybin V., Schmidt A., Yus E., Aebersold R., Herrmann R., Böttcher B., Frangakis A.S., Russell R.B., Serrano L., Bork P. and Gavin A.C. (2009). Proteome organization in a genome- reduced bacterium. Science 326, 1235-1240.

Patent applications:

  1. Giant liposome array for high-throughput lipid-protein interaction screening. International patent application PCT/EP2013/065256. July 19, 2013.